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. 1988 Jul;30(3):307-12.
doi: 10.1016/0090-8258(88)90244-2.

Ovarian cancer: the prognostic value of the serum half-life of CA125 during induction chemotherapy

M E van der Burg  1 , F B Lammes, W L van Putten, G Stoter
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Ovarian cancer: the prognostic value of the serum half-life of CA125 during induction chemotherapy

M E van der Burg et al. Gynecol Oncol. 1988 Jul.

Abstract

Eighty-five patients with epithelial ovarian cancer were studied to assess the prognostic value of the prechemotherapy serum concentration of CA125 and its half-life during induction therapy. The endpoints of the analysis were progression rate and time to progression. The prechemotherapy CA125 level had no prognostic value (P = 0.36) if the patients were stratified for tumor size. The half-life of CA125, however, was an independent prognostic variable (P = 0.01). Patients with a half-life of 20 days and more had a 3.2 times higher progression rate and a significantly shorter median time to progression of only 11 months, as compared to 43 months for patients with a half-life of less than 20 days.

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