Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jan;9(1):28-38.
doi: 10.1002/sctm.19-0205. Epub 2019 Oct 24.

Mesenchymal stem cell-derived extracellular vesicles for the treatment of acute respiratory distress syndrome

Aswin Abraham  1 , Anna Krasnodembskaya  1
Affiliations
Review

Mesenchymal stem cell-derived extracellular vesicles for the treatment of acute respiratory distress syndrome

Aswin Abraham et al. Stem Cells Transl Med. 2020 Jan.

Abstract

Acute respiratory distress syndrome (ARDS) is a serious and potentially fatal acute inflammatory lung condition which currently has no specific treatments targeting its pathophysiology. However, mesenchymal stem cells have been shown to have very promising therapeutic potential, and recently, it has been established that their effect is largely due to the transfer of extracellular vesicles (EVs). EVs have been shown to transfer a variety of substances such as mRNA, miRNA, and even organelles such as mitochondria in order to ameliorate ARDS in preclinical models. In addition, the fact that they have been proven to have the same effect as their parent cells combined with their numerous advantages over whole cell administration means that they are a promising candidate for clinical application that merits further research.

Keywords: cellular therapy; clinical translation; mesenchymal stem cells (MSCs); respiratory tract.

PubMed Disclaimer

Conflict of interest statement

The authors declared no potential conflict of interest.

Figures

Figure 1
Figure 1
Transfer of miRNA, mRNA, and mitochondria from mesenchymal stem cells (MSCs) to different target cells by extracellular vesicles (EVs)
See this image and copyright information in PMC

Comment in

References

    1. Ashbaugh D, Bigelow DB, Petty T, Levine B. Acute respiratory distress in adults. Lancet. 1967;290:319‐323. - PubMed
    1. Force AD, Ranieri VM, Rubenfeld GD. Acute respiratory distress syndrome. JAMA. 2012;307:2526‐2533. - PubMed
    1. Fan E, Brodie D, Slutsky AS. Acute respiratory distress syndrome: advances in diagnosis and treatment. JAMA. 2018;319:698‐710. - PubMed
    1. Máca J, Jor O, Holub M, et al. Past and present ARDS mortality rates: a systematic review. Respir Care. 2017;62:113‐122. - PubMed
    1. Herridge MS, Tansey CM, Matté A, et al. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med. 2011;364:1293‐1304. - PubMed

Publication types

MeSH terms