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. 2019 Oct 22;3(20):3136-3142.
doi: 10.1182/bloodadvances.2019000311.

Association between the HLA-DRB1*03:01-DQB1*02:01 haplotype and PF4/heparin antibodies

Ray Zhang  1 , Brian F Duffy  2 , Vinzenz Lange  3 , Charles S Eby  1   4 , Chang Liu  1
Affiliations

Association between the HLA-DRB1*03:01-DQB1*02:01 haplotype and PF4/heparin antibodies

Ray Zhang et al. Blood Adv. .

Abstract

  1. HLA-DRB1*03:01-DQB1*02:01 haplotype patients develop higher anti–platelet factor 4/heparin (PF4/H) levels following IV heparin exposure.

  2. HLA-restricted antigen presentation may play a role in the formation of anti-PF4/H antibodies.

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
Figure 1.
Figure 1.
Figure 2.
Figure 2.
Association between HLA and anti-PF4/H antibody levels. (A) HLA allele associations: top row, distribution of OD values; middle row, odds ratio for having an OD value above vs below a given cutoff; and bottom row, significance of association across all possible cutoffs (95% confidence intervals in pink). (B) HLA amino acid residue associations: top row, distribution of OD values; middle row, odds ratio for having an OD value above vs below a given cutoff; and bottom row, significance of association across all possible cutoffs (95% confidence intervals in pink). (C) Two views of candidate amino acid residues within DRB1 driving risk for anti-PF4/H antibody development (Protein Data Bank code: 1A6A). *Significance within a 5% false discovery rate.
Figure 2.
Figure 2.
Association between HLA and anti-PF4/H antibody levels. (A) HLA allele associations: top row, distribution of OD values; middle row, odds ratio for having an OD value above vs below a given cutoff; and bottom row, significance of association across all possible cutoffs (95% confidence intervals in pink). (B) HLA amino acid residue associations: top row, distribution of OD values; middle row, odds ratio for having an OD value above vs below a given cutoff; and bottom row, significance of association across all possible cutoffs (95% confidence intervals in pink). (C) Two views of candidate amino acid residues within DRB1 driving risk for anti-PF4/H antibody development (Protein Data Bank code: 1A6A). *Significance within a 5% false discovery rate.
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