Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Nov;121(11):966-972.
doi: 10.1038/s41416-019-0606-3. Epub 2019 Oct 25.

Impact of neuroendocrine morphology on cancer outcomes and stage at diagnosis: a UK nationwide cohort study 2013-2015

Tracey S E Genus  1   2 , Catherine Bouvier  3 , Kwok F Wong  4 , Rajaventhan Srirajaskanthan  5   6 , Brian A Rous  7 , Denis C Talbot  8 , Juan W Valle  9 , Mohid Khan  10 , Neil Pearce  11 , Mona Elshafie  12 , Nicholas S Reed  13 , Eileen Morgan  14 , Andrew Deas  15 , Ceri White  16 , Dyfed Huws  16 , John Ramage  5   6
Affiliations

Impact of neuroendocrine morphology on cancer outcomes and stage at diagnosis: a UK nationwide cohort study 2013-2015

Tracey S E Genus et al. Br J Cancer. 2019 Nov.

Abstract

Background: The diagnosis of neuroendocrine neoplasms (NENs) is often delayed. This first UK population-based epidemiological study of NENs compares outcomes with non-NENs to identify any inequalities.

Methods: Age-standardised incidence rate (ASR), 1-year overall survival, hazard ratios and standardised mortality rates (SMRs) were calculated for all malignant NENs diagnosed 2013-2015 from UK national Public Health records. Comparison with non-NENs assessed 1-year overall survival (1YS) and association between diagnosis at stage IV and morphology.

Results: A total of 15,222 NENs were identified, with an ASR (2013-2015 combined) of 8.6 per 100,000 (95% CI 8.5-8.7); 4.6 per 100 000 (95% CI, 4.5-4.7) for gastro-entero-pancreatic (GEP) NENs. The 1YS was 75% (95% CI, 73.9-75.4) varying significantly by sex. Site and morphology were prognostic. NENs (predominantly small cell carcinomas) in the oesophagus, bladder, prostate, and female reproductive organs had a poorer outcome and were three times more likely to be diagnosed at stage IV than non-NENs.

Conclusion: Advanced stage at diagnosis with significantly poorer outcomes of some NENs compared with non-NENs at the same anatomical site, highlight the need for improved access to specialist services and targeted service improvement.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Annual incidence (line graph) and count (bar chart) of NENs diagnosed in England 2001–2015 and the UK 2015 (cross markers)
See this image and copyright information in PMC

References

    1. Kunz PL, Reidy-Lagunes D, Anthony LB, Bertino EM, Brendtro K, Chan JA, et al. Consensus guidelines for the management and treatment of neuroendocrine tumors. Pancreas. 2013;42:557–577. doi: 10.1097/MPA.0b013e31828e34a4. - DOI - PMC - PubMed
    1. Singh S, Granberg D, Wolin E, Warner R, Sissons M, Kolarova T, et al. Patient-reported burden of a neuroendocrine tumor (NET) diagnosis: results from the first global survey of patients with NETs. J. Glob. Oncol. 2016;3:43–53. doi: 10.1200/JGO.2015.002980. - DOI - PMC - PubMed
    1. Fritz A., Percy C., Jack A., Shanmugaratnam K., Sobin L., Max Parkin D. (eds.). International Classification of Diseases for Oncology, 3rd edn, first revision. (World Health Organization, Geneva, 2013).
    1. Sobin L. H., Gospodarowicz M. K., Wittekind C. International Union Against Cancer TNM Classification of Malignant Tumors, 7th edn. (John Wiley & Sons, Hoboken, 2011).
    1. Edge S. E., Byrd D. R., Carducci M. A., Compton C. C., Fritz A. G., Greene F. L. et al. American Joint Committee on Cancer (AJCC) TNM staging for NETs. AJCC Cancer Staging Manual, 7th edn. (Springer, New York, 2010).

Publication types

MeSH terms