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. 2019 Dec;64(9):1261-1271.
doi: 10.1007/s00038-019-01298-x. Epub 2019 Nov 15.

Cost-effectiveness of precision medicine: a scoping review

Miriam Kasztura  1 , Aude Richard  2 , Nefti-Eboni Bempong  2 , Dejan Loncar  2 , Antoine Flahault  2
Affiliations

Cost-effectiveness of precision medicine: a scoping review

Miriam Kasztura et al. Int J Public Health. 2019 Dec.

Abstract

Objectives: Precision medicine (PM) aims to improve patient outcomes by stratifying or individualizing diagnosis and treatment decisions. Previous reviews found inconclusive evidence as to the cost-effectiveness of PM. The purpose of this scoping review was to describe current research findings on the cost-effectiveness of PM and to identify characteristics of cost-effective interventions.

Methods: We searched PubMed with a combination of terms related to PM and economic evaluations and included studies published between 2014 and 2017.

Results: A total of 83 articles were included, of which two-thirds were published in Europe and the USA. The majority of studies concluded that the PM intervention was at least cost-effective compared to usual care. However, the willingness-to-pay thresholds varied widely. Key factors influencing cost-effectiveness included the prevalence of the genetic condition in the target population, costs of genetic testing and companion treatment and the probability of complications or mortality.

Conclusions: This review may help inform decisions about reimbursement, research and development of PM interventions.

Keywords: Economic evaluation; Precision medicine; Scoping review.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Search strategy
Fig. 2
Fig. 2
PRISMA flowchart showing the number of studies at each stage of the review process
See this image and copyright information in PMC

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