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. 2019 Nov 15;33(11):1446-1451.
doi: 10.7507/1002-1892.201903074.

[Research progress in treatment of knee osteoarthritis by paracrine effect of stem cells]

[Article in Chinese]
Wenbo Chen  1 , Jiangyu Cai  1 , Yaying Sun  1 , Jun Chen  1 , Shiyi Chen  2
Affiliations

[Research progress in treatment of knee osteoarthritis by paracrine effect of stem cells]

[Article in Chinese]
Wenbo Chen et al. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. .

Abstract
in English, Chinese

Objective: To review the advances in utilizing paracrine effect of stem cells in knee osteoarthritis (OA) treatment.

Methods: The researches in applying stem cells derived conditioned medium, extracellular matrix, exosomes, and microvesicles in knee OA treatment and cartilage repair were reviewed and analyzed.

Results: The satisfying outcomes of using different products of stem cells paracrine effect in knee OA condition as well as cartilage defect is revealed in studies in vitro and in vivo. The mechanism including suppressing the intraarticular inflammation, the apoptosis of chondrocytes, and the degradation of cartilage matrix, while enhancing the synthesis of cartilage matrix, the differentiation of in-situ stem cells into chondrocytes and the migration to the affected area. The effectiveness can be further improved supplemented with the tissue engineering methods or gene modification.

Conclusion: Compared with the traditional stem cell therapy, applying the products from paracrine effect of stem cells in knee OA treatment is more economical and safer, presenting great potential in clinical practice.

目的: 综述现阶段应用干细胞旁分泌效应治疗膝部骨关节炎（osteoarthritis，OA）的研究进展。.

方法: 查阅近年来干细胞来源条件培养液、细胞外基质、外泌体及微囊泡在膝部 OA 及软骨修复领域的相关基础研究，并进行总结分析。.

结果: 干细胞旁分泌效应对膝部 OA 及关节软骨损伤的治疗效果，在不同层面的多项研究中已有所彰显。其作用机制包括对关节腔内炎性反应、软骨细胞凋亡、软骨基质水解的有效抑制，以及促进软骨基质合成、原位固有干细胞向软骨细胞定向分化、并向损伤部位定向迁移等修复过程。结合组织工程学方法或基因修饰等手段能进一步提升疗效。.

结论: 相较传统干细胞疗法，应用干细胞旁分泌效应产物治疗膝部 OA 更为安全且经济，具有较高的临床转化价值。.

Keywords: Osteoarthritis; exosome; extracellular matrix; microvesicle; paracrine effect; stem cells therapy.

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Conflict of interest statement

利益冲突：所有作者声明，在课题研究和文章撰写过程中不存在利益冲突。课题经费支持没有影响文章观点和对研究数据客观结果的统计分析及其报道。

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