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Multicenter Study
. 2020 Aug 1;147(3):648-661.
doi: 10.1002/ijc.32753. Epub 2019 Nov 23.

Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition

Nathalie Kliemann  1 , Neil Murphy  1 , Vivian Viallon  1 , Heinz Freisling  1 , Konstantinos K Tsilidis  2   3 , Sabina Rinaldi  1 , Francesca R Mancini  4   5   6   7 , Guy Fagherazzi  4   5   6   7 , Marie-Christine Boutron-Ruault  4   5   6   7 , Heiner Boeing  8 , Matthias B Schulze  9   10 , Giovanna Masala  11 , Vittorio Krogh  12 , Carlotta Sacerdote  13 , Maria S de Magistris  14 , Bas Bueno-de-Mesquita  2   15   16   17 , Elisabete Weiderpass  1   18 , Tilman Kühn  19 , Rudolf Kaaks  19 , Paula Jakszyn  20   21 , Daniel Redondo-Sánchez  22   23   24 , Pilar Amiano  22   25 , Maria-Dolores Chirlaque  22   26 , Aurelio B Gurrea  22   27   28 , Ulrica Ericson  29 , Isabel Drake  29 , Therese H Nøst  18 , Dagfinn Aune  2   30   31 , Anne M May  32 , Anne Tjønneland  33 , Christina C Dahm  34 , Kim Overvad  34   35 , Rosario Tumino  36 , Jose R Quirós  37 , Antonia Trichopoulou  38 , Anna Karakatsani  38   39 , Carlo La Vecchia  38   40 , Lena M Nilsson  41 , Elio Riboli  2 , Inge Huybrechts  1 , Marc J Gunter  1
Affiliations
Free article
Multicenter Study

Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition

Nathalie Kliemann et al. Int J Cancer. .
Free article

Abstract

Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD ]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD : 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD : 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD : 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD : 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD : 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD : 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.

Keywords: basal metabolic rate; cancer; metabolic disorder; obesity.

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References

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