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Editorial
. 2019 Oct 25;294(43):15575-15576.
doi: 10.1074/jbc.H119.011130.

A new role for vault RNA-TEP1 complexes in mRNA production in trypanosomes

Valerie A Kickhoefer  1   2
Affiliations
Editorial

A new role for vault RNA-TEP1 complexes in mRNA production in trypanosomes

Valerie A Kickhoefer. J Biol Chem. .

Abstract

Vault RNAs, found in vault ribonucleoprotein complexes, are known to be one of many types of small noncoding RNAs (ncRNAs), but their specific function is not known. A new study identifies a small ncRNA from Trypanosome brucei as a vault RNA (vtRNA) based on sequence analysis and its association with the canonical vault component TEP1. Down-regulation of T. brucei vtRNA impairs mRNA splicing in a permeabilized cell system, suggesting new roles for these enigmatic biomolecules.

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Conflict of interest statement

The author declares that she has no conflicts of interest with the contents of this article.

Comment on

References

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