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. 2019 Nov 30:293:110988.
doi: 10.1016/j.pscychresns.2019.110988. Epub 2019 Oct 8.

Neuroimaging predictors of response to cognitive remediation and social skills training: A pilot study in veterans with schizophrenia

Margaret M McClure  1 , Fiona S Graff  2 , Joseph Triebwasser  3 , M Mercedes Perez-Rodriguez  4 , Daniel R Rosell  4 , Philip R Szeszko  5 , King-Wai Chu  6 , Antonia S New  4 , Larry J Siever  5 , Erin A Hazlett  7
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Neuroimaging predictors of response to cognitive remediation and social skills training: A pilot study in veterans with schizophrenia

Margaret M McClure et al. Psychiatry Res Neuroimaging. .

Abstract

Neuroimaging may predict response to cognitive remediation therapy and social skills training (CRT + SST) in schizophrenia. Identifying biological predictors of response is crucial for treatment decision making given not all patients respond to such interventions. Nineteen veterans with schizophrenia enrolled in an 8-week trial of CRT + SST. Ten participants completed diffusion tensor imaging (DTI) at baseline. Baseline fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF) and overall average FA predicted improvements in visual-spatial working memory, and social cognition, respectively. Neuroimaging may be useful in identifying therapeutic targets in schizophrenia.

Keywords: Cognitive remediation; Diffusion tensor imaging; Schizophrenia; Social skills training.

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