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Review
. 2020 Oct;26(4):2057-2066.
doi: 10.1007/s12253-019-00765-3. Epub 2019 Oct 26.

Review: Ewing Sarcoma Predisposition

Pablo Gargallo  1 , Yania Yáñez  2 , Antonio Juan  3 , Vanessa Segura  2 , Julia Balaguer  3 , Bárbara Torres  3 , Silves Oltra  4   5 , Victoria Castel  3 , Adela Cañete  3
Affiliations
Free article
Review

Review: Ewing Sarcoma Predisposition

Pablo Gargallo et al. Pathol Oncol Res. 2020 Oct.
Free article

Abstract

Ewing sarcoma is a rare tumor developed in bone and soft tissues of children and teenagers. This entity is biologically led by a chromosomal translocation, typically including EWS and FLI1 genes. Little is known about Ewing sarcoma predisposition, although the role of environmental factors, ethnicity and certain polymorphisms on Ewing sarcoma susceptibility has been studied during the last few years. Its prevalence among cancer predisposition syndromes has also been thoroughly examined. This review summarizes the available evidence on predisposing factors involved in Ewing sarcoma susceptibility. On the basis of these data, an integrated approach of the most influential factors on Ewing sarcoma predisposition is proposed.

Keywords: Cancer predisposition; Ewing sarcoma; Genetic susceptibility; Polymorphism.

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References

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