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. 2019 Oct;79(10):1043-1060.
doi: 10.1055/a-0882-4116. Epub 2019 Oct 22.

Sarcoma of the Uterus. Guideline of the DGGG and OEGGG (S2k Level, AWMF Register Number 015/074, February 2019)

Dominik Denschlag  1 , Sven Ackermann  2 , Marco Johannes Battista  3 , Wolfgang Cremer  4 , Gerlinde Egerer  5 , Markus Follmann  6 , Heidemarie Haas  7 , Philipp Harter  8 , Simone Hettmer  9 , Lars-Christian Horn  10 , Ingolf Juhasz-Boess  11 , Karin Kast  12 , Günter Köhler  13 , Thomas Kröncke  14 , Katja Lindel  15 , Peter Mallmann  16 , Regine Meyer-Steinacker  17 , Alexander Mustea  18 , Edgar Petru  19 , Peter Reichardt  20 , Dietmar Schmidt  21 , Hans-Georg Strauss  22 , Clemens Tempfer  23 , Falk Thiel  24 , Uwe Ulrich  25 , Thomas Vogl  26 , Dirk Vordermark  27 , Paul Gass  28 , Matthias W Beckmann  28
Affiliations

Sarcoma of the Uterus. Guideline of the DGGG and OEGGG (S2k Level, AWMF Register Number 015/074, February 2019)

Dominik Denschlag et al. Geburtshilfe Frauenheilkd. 2019 Oct.

Abstract

Aims This is an official guideline published and coordinated by the German Society of Gynecology and Obstetrics (DGGG) and the Austrian Society of Gynecology and Obstetrics (OEGGG). Because of their rarity and heterogeneous histopathology, uterine sarcomas are challenging in terms of how they should be managed clinically, and treatment requires a multidisciplinary approach. To our knowledge, there are currently no binding evidence-based recommendations for the appropriate management of this heterogeneous group of tumors. Methods This S2k guideline was first published in 2015. The update published here is the result of the consensus of a representative interdisciplinary group of experts who carried out a systematic search of the literature on uterine sarcomas in the context of the guidelines program of the DGGG, OEGGG and SGGG. Members of the participating professional societies achieved a formal consensus after a moderated structured consensus process. Recommendations The consensus-based recommendations and statements include the epidemiology, classification, staging, symptoms, general diagnostic work-up and general pathology of uterine sarcomas as well as the genetic predisposition to develop uterine sarcomas. Also included are statements on the management of leiomyosarcomas, (low and high-grade) endometrial stromal sarcomas and undifferentiated uterine sarcomas and adenosarcomas. Finally, the guideline considers the follow-up and morcellation of uterine sarcomas and the information provided to patients.

Keywords: adenosarcoma; endometrial stromal sarcoma; leiomyosarcoma; morcellation; uterine sarcoma.

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Conflict of interest statement

Conflict of Interest/Interessenkonflikt The authorsʼ conflicts of interest are listed in the long version of the guideline./Die Interessenkonflikte der Autoren sind in der Langfassung der Leitlinie aufgelistet.

Figures

Fig. 1
Fig. 1
Diagnostic algorithm of smooth muscle tumors of the uterus. [rerif]
Fig. 2
Fig. 2
Synopsis of the morphology, immunohistochemistry and molecular pathology of endometrial stromal sarcomas (ESS) and undifferentiated uterine sarcomas (UUS). [rerif]
Abb. 1
Abb. 1
Diagnostischer Algorithmus glattmuskulärer Tumoren des Uterus. [rerif]
Abb. 2
Abb. 2
Synopsis der Morphologie, Immunhistochemie und Molekularpathologie endometrialer Stromasarkome (ESS) und undifferenzierter uteriner Sarkome (UUS). [rerif]
See this image and copyright information in PMC

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