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Meta-Analysis
. 2019 Jun;19(2):2121-2129.
doi: 10.4314/ahs.v19i2.36.

Modifiable and non-modifiable risk factors in ischemic stroke: a meta-analysis

Qinyuan Cui  1 , Niyaz Ahmad Naikoo  1
Affiliations
Meta-Analysis

Modifiable and non-modifiable risk factors in ischemic stroke: a meta-analysis

Qinyuan Cui et al. Afr Health Sci. 2019 Jun.

Abstract

Background: Stroke is a heterogeneous, multifactorial disease regulated by modifiable and non-modifiable risk factors like total cholesterol, triglycerides, high density lipid-cholesterol (HDL-C), low density lipid-cholesterol (LDL-C) and glucose and non-modifiable factors like age. Evaluation of these risk factors for ischemic stroke may contribute to more effective prevention.

Methods: This meta-analysis investigated the data up to 2018 with respect to age, total cholesterol, triglycerides, high density lipid-cholesterol (HDL-C), low density lipid-cholesterol (LDL-C) and glucose levels in the Ischemic stroke patients and controls. Data from each eligible study was extracted such as year of publication, first author name, ethnicity/country, number of ischemic stroke patients and healthy controls and studies were subjected to heterogeneity analysis.

Results: Meta-analysis of the modifiable and non-modifiable risk factors like total cholesterol, HDL-C and LDL-C glucose, triglycerides levels and age were not having significantly associated with ischemic stroke (p>0.05). However meta-analysis of triglyceride yielded significant association ischemic stroke with overall 95% CI (-0.62- (-0.09) and P= 0.007 and glucose also showed significant association with ischemic stroke with 95% CI (-1.08- (-0.14), P=0.01. Studies were subjected to heterogeneity which revealed significant heterogeneity with (P<0.00) and I2>96%.

Conclusion: Meta-analysis revealed that levels of triglyceride and glucose are the predisposing factors for ischemic stroke in the Asian population.

Keywords: Ischemic stroke; meta-analysis; modifiable; non-modifiable; risk factors.

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Figures

Fig 1
Fig 1
Flow chart
Fig 2
Fig 2
Forest plots showing effect of triglycerides and total cholesterol on ischemic stroke.
Fig 3
Fig 3
Forest plots showing effect of High Density Lipid- Cholesterol (HDL-C) and Low Density Lipid- Cholesterol (LDL-C) on ischemic stroke.
Fig 4
Fig 4
Forest plots showing effect of Glucose and age on ischemic stroke.
See this image and copyright information in PMC

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