Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jun;19(2):2147-2155.
doi: 10.4314/ahs.v19i2.39.

Association of inflammatory biomarkers with lung cancer in North Indian population

Priyanka Gaur  1 , Sandeep Bhattacharya  1 , Surya Kant  2 , Ras Kushwaha  2 , Rajiv Garg  2 , Gaurav Singh  3 , Sarika Pandey  2 , Supriya Sharma  4
Affiliations

Association of inflammatory biomarkers with lung cancer in North Indian population

Priyanka Gaur et al. Afr Health Sci. 2019 Jun.

Abstract

Background: Lung cancer is characterized by uncontrolled cell growth of the lung tissues. It is the leading cause of cancer-related deaths worldwide.

Objectives: The study aimed to determine the circulating CRP, TNF-α, IL-6 and IL-8 levels in lung cancer and healthy control and also established association between these biomarkers with the smoking status as well as the stages of the disease.

Methodology: 51 lung cancer patients and 51 healthy controls were enrolled in this case-control study. The serum levels of CRP, TNF-α, IL-6 and IL-8 were measured in lung cancer patients and healthy control groups.

Results: The levels of serum CRP, TNF-α, IL-6 and IL-8 were significantly higher in lung cancer patients when compared with controls(P<0.0001). The levels of these biomarkers were also significantly higher in stage iii/iv as compared to stage i/ii(P<0.001). Significant difference in the levels of these biomarkers were also found in smoker and non-smoker lung cancer patients as compared to controls(P<0.001).

Conclusion: CRP, TNF-α, IL-6 and IL-8 are the promising biomarkers in the identification of lung cancer patients. The study also supports the association of inflammatory markers to lung cancer risk. Hence these findings suggest the levels of these biomarkers could be a useful tool for guiding the diagnosis of lung cancer.

Keywords: Lung cancer; biomarker; inflammation; smoking; stage.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Comparison of serum CRP, TNF-α, IL6 and IL-8 Levels between lung cancer patient and healthy controls. Data are expressed as mean and compared by unpaired t-test. p-values < 0.05 are considered significant.
Figure 2
Figure 2
Comparison of Serum CRP, TNF-α, IL-6 and IL-8 between Different Stages of Lung Cancer and Healthy Controls. Data presented as mean and compared by one-way analysis of variance (ANOVA) followed by Boneferroni post-test for multiple comparisons. p-values < 0.05 are considered significant.
Figure 3
Figure 3
Comparison of Serum CRP, TNF-α, IL-6 and IL-8 Levels Between Smokers and Non-smokers lung cancer patients and Smokers and Non-smokers Healthy controls. Data presented as mean and compared by one-way analysis of variance (ANOVA) test followed by Bonferroni post-test for multiple comparisons. p-values < 0.05 are considered significant
See this image and copyright information in PMC

References

    1. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics. CA Cancer J Clin. 2014;64(1):9–29. - PubMed
    1. Mack CL. Serum cytokines as biomarkers of disease and clues to pathogenesis. Hepatology. 2007;46(1):6–8. - PubMed
    1. Seruga B, Zhang H, Bernstein LJ, Tannock IF. Cytokines and their relationship to the symptoms and outcome of cancer. Nat Rev Cancer. 2008;8(11):887–899. - PubMed
    1. Smyth MJ, Cretney E, Kershaw MH, Hayakawa Y. Cytokines in cancer immunity and immunotherapy. Immunol Rev. 204;202(1):275–293. PubMed. - PubMed
    1. Chang CH, Hsiao CF, Yeh YM, Chang GC, Tsai YH, et al. Circulating interleukin-6 level is a prognostic marker for survival in advanced nonsmall cell lung cancer patients treated with chemotherapy. Int J Cancer. 2013;132(9):1977–1985. PubMed. - PubMed