Patient selection in sepsis: precision medicine using phenotypes and its implications for future clinical trial design

Affiliations

Editorial

Daisuke Hasegawa et al. J Thorac Dis. 2019 Sep.

. 2019 Sep;11(9):3672-3675.

doi: 10.21037/jtd.2019.09.31.

¹ Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, Aichi, Japan.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis.
Seymour CW, Kennedy JN, Wang S, Chang CH, Elliott CF, Xu Z, Berry S, Clermont G, Cooper G, Gomez H, Huang DT, Kellum JA, Mi Q, Opal SM, Talisa V, van der Poll T, Visweswaran S, Vodovotz Y, Weiss JC, Yealy DM, Yende S, Angus DC. Seymour CW, et al. JAMA. 2019 May 28;321(20):2003-2017. doi: 10.1001/jama.2019.5791. JAMA. 2019. PMID: 31104070 Free PMC article.

1. Seymour CW, Kennedy JN, Wang S, et al. Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis. JAMA 2019;321:2003-17. 10.1001/jama.2019.5791 - DOI - PMC - PubMed
1. Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 2016;315:801-10. 10.1001/jama.2016.0287 - DOI - PMC - PubMed
1. Vincent JL. Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? No. Intensive Care Med 2016;42:1778-80. 10.1007/s00134-016-4482-5 - DOI - PubMed
1. ARDS Definition Task Force ., Ranieri VM, Rubenfeld GD, et al. Acute respiratory distress syndrome: the Berlin definition. JAMA 2012;307:2526-33. - PubMed
1. Thomas ME, Blaine C, Dawnay A, et al. The definition of acute kidney injury and its use in practice. Kidney Int 2015;87:62-73. 10.1038/ki.2014.328 - DOI - PubMed