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Editorial
. 2019 Sep;11(9):3676-3680.
doi: 10.21037/jtd.2019.09.26.

Probability of benefit with the use of neuromuscular blockade in patients with acute respiratory distress syndrome

Guilherme Martins de Souza  1 , Felipe Souza Lima Vianna  1 , Thais Dias Midega  1 , Ary Serpa Neto  1   2   3
Affiliations
Editorial

Probability of benefit with the use of neuromuscular blockade in patients with acute respiratory distress syndrome

Guilherme Martins de Souza et al. J Thorac Dis. 2019 Sep.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Results of the Bayesian hierarchical meta-analysis. (A) Posterior probability distribution of the pooled results of the meta-analysis (full posterior density from the Markov chain Monte Carlo approach, the red area is where risk ratio >1 and NMBA increase mortality); (B) resulting estimated posterior probability that the risk ratio for mortality exceeds that threshold value according to different down-weightings of previous studies (if these weights are equal to 1, a meta-analysis of all studies are carried out, on the other hand, with the decrease in these weights, the importance of previous studies decrease and when these weights are equal to 0, then we learn nothing about the risk ratio for NMBA from previous studies, and with a minimally informative prior the results represent the analysis of the ROSE trial alone). ROSE trial, Reevaluation of Systemic Early Neuromuscular Blockade trial; NMBA, neuromuscular blocking agents.
See this image and copyright information in PMC

Comment on

  • Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.
    National Heart, Lung, and Blood Institute PETAL Clinical Trials Network; Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus DC. National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, et al. N Engl J Med. 2019 May 23;380(21):1997-2008. doi: 10.1056/NEJMoa1901686. Epub 2019 May 19. N Engl J Med. 2019. PMID: 31112383 Free PMC article. Clinical Trial.

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