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. 2019 Sep 17;8(1):150-158.
doi: 10.1080/21556660.2019.1669610. eCollection 2019.

Real-world treatment patterns among patients with advanced gastric cancer in Russia: a chart review study

Sergei A Tjulandin  1 , Alexey A Tryakin  1 , Natalia S Besova  1 , Evgeniya Sholokhova  2 , Jasmina I Ivanova  3 , Wendy Y Cheng  3 , Luke M Schmerold  3 , Philippe Thompson-Leduc  3 , Diego Novick  4
Affiliations

Real-world treatment patterns among patients with advanced gastric cancer in Russia: a chart review study

Sergei A Tjulandin et al. J Drug Assess. .

Abstract

Objective: Little evidence is available on the management of patients with metastatic and/or unresectable gastric cancer (mGC) after the failure of first-line treatment. This study presents real-world data on characteristics and treatment patterns of patients with mGC in Russia. Methods: Eligible patients were ≥18 years old, diagnosed with mGC ≥ January 1, 2012, received first-line chemotherapy followed by second-line chemotherapy or best supportive care (BSC), had ≥3 months of follow-up after the start of second-line chemotherapy or BSC (except in cases of death), and had not participated in a clinical trial. Data were summarized using descriptive statistics. Results: A total of 88 physicians provided data from 202 charts. Mean age at mGC diagnosis was 53.7 (standard deviation: 11.2) years; 70.8% of patients were male. Reasons for first-line treatment discontinuation included disease progression (50.5%) and adverse events/toxicity (39.1%). There were 52 unique treatment regimens prescribed in second-line; capecitabine (14.5%), paclitaxel (9.3%), and capecitabine + oxaliplatin (8.7%) were the most frequent. Reasons for second-line treatment discontinuation included disease progression (39.8%) and patient refusal to continue (37.5%). During 2nd-line treatment, the most common treatment-related symptoms were nausea/vomiting (75.0%), while pain (73.8%) was the most common disease-related symptom. Antiemetics (63.4%), chemotherapy (61.6%), non-narcotic analgesics (48.3%), endoscopy (45.9%), and nutritional support (35.5%) were most frequently used as supportive care. Conclusions: Second-line treatment patterns for patients with mGC in Russia are heterogeneous. Results of this study indicate the need for more intensive implementation of the most active regimens in second-line treatment of mGC according to international and national guidelines.

Keywords: (MeSH): gastrointestinal neoplasms; Russia; drug therapy; palliative care; stomach neoplasms.

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Figures

Figure 1.
Figure 1.
Physician-reported symptoms (% of patients) by line of therapy.
See this image and copyright information in PMC

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