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Editorial
. 2019 Sep;7(Suppl 6):S195.
doi: 10.21037/atm.2019.07.23.

Implications of the circular RNAs in localized prostate cancer

Shivansh Nigam  1 , Nishat Manzar  1 , Bushra Ateeq  1
Affiliations
Editorial

Implications of the circular RNAs in localized prostate cancer

Shivansh Nigam et al. Ann Transl Med. 2019 Sep.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Biogenesis and downstream functions of circCSNK1G3 in prostate cancer. Schema showing the biogenesis of circular RNA, circCSNK1G3 via aberrant splicing events such as back-splicing and its emerging roles in localized prostate cancer, namely, miRNA sponge which sequesters miRNA-181b/d, cell proliferation, and prognostic factor.
See this image and copyright information in PMC

Comment on

  • Widespread and Functional RNA Circularization in Localized Prostate Cancer.
    Chen S, Huang V, Xu X, Livingstone J, Soares F, Jeon J, Zeng Y, Hua JT, Petricca J, Guo H, Wang M, Yousif F, Zhang Y, Donmez N, Ahmed M, Volik S, Lapuk A, Chua MLK, Heisler LE, Foucal A, Fox NS, Fraser M, Bhandari V, Shiah YJ, Guan J, Li J, Orain M, Picard V, Hovington H, Bergeron A, Lacombe L, Fradet Y, Têtu B, Liu S, Feng F, Wu X, Shao YW, Komor MA, Sahinalp C, Collins C, Hoogstrate Y, de Jong M, Fijneman RJA, Fei T, Jenster G, van der Kwast T, Bristow RG, Boutros PC, He HH. Chen S, et al. Cell. 2019 Feb 7;176(4):831-843.e22. doi: 10.1016/j.cell.2019.01.025. Cell. 2019. PMID: 30735634

References

    1. Li X, Yang L, Chen LL. The biogenesis, functions, and challenges of circular RNAs. Mol Cell 2018;71:428-42. 10.1016/j.molcel.2018.06.034 - DOI - PubMed
    1. Vo JN, Cieslik M, Zhang Y, et al. The Landscape of Circular RNA in Cancer. Cell 2019;176:869-81.e13. 10.1016/j.cell.2018.12.021 - DOI - PMC - PubMed
    1. Chen S, Huang V, Xu X, et al. Widespread and Functional RNA Circularization in Localized Prostate Cancer. Cell 2019;176:831-43.e22. 10.1016/j.cell.2019.01.025 - DOI - PubMed
    1. Fraser M, Sabelnykova VY, Yamaguchi TN, et al. Genomic hallmarks of localized, non-indolent prostate cancer. Nature 2017;541:359. 10.1038/nature20788 - DOI - PubMed
    1. Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA 2013;19:141-57. 10.1261/rna.035667.112 - DOI - PMC - PubMed