Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2019 Sep;7(Suppl 6):S237.
doi: 10.21037/atm.2019.08.14.

Managing intrinsic pro-degradatory mechanical and cellular cycles in the development of osteochondral lesions

Seok Jung Kim  1 , Asode Ananthram Shetty  2 , Saif Ahmed  2 , Neha Shetty  2 , Sang Heon Lee  1
Affiliations
Editorial

Managing intrinsic pro-degradatory mechanical and cellular cycles in the development of osteochondral lesions

Seok Jung Kim et al. Ann Transl Med. 2019 Sep.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Degenerative arthropathy is progressive as, once established, the damage response further compromises structural integrity.
See this image and copyright information in PMC

Comment on

References

    1. Jeffrey JE, Thomson LA, Aspden RM. Matrix loss and synthesis following a single impact load on articular cartilage in vitro. Biochim Biophys Acta 1997;1334:223-32. 10.1016/S0304-4165(96)00097-9 - DOI - PubMed
    1. Steinmeyer J, Knue S. The proteoglycan metabolism of mature bovine articular cartilage explants superimposed to continuously applied cyclic mechanical loading. Biochem Biophys Res Commun 1997;240:216-21. 10.1006/bbrc.1997.7641 - DOI - PubMed
    1. Monfort J, Garcia-Giralt N, López-Armada MJ, et al. Decreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulation. Arthritis Res Ther 2006;8:R149. 10.1186/ar2042 - DOI - PMC - PubMed
    1. Blain EJ, Gilbert SJ, Wardale RJ, et al. Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro. Arch Biochem Biophys 2001;396:49-55. 10.1006/abbi.2001.2575 - DOI - PubMed
    1. Livne E, Laufer D, Blumenfeld I. Differential response of articular cartilage from young growing and mature old mice to IL-1 and TGF-beta. Arch Gerontol Geriatr 1997;24:211-21. 10.1016/S0167-4943(96)00753-4 - DOI - PubMed