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. 1988 Aug 29;236(2):321-4.
doi: 10.1016/0014-5793(88)80047-4.

Phosphorylation of smooth muscle caldesmon by three protein kinases: implication for domain mapping

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Free article

Phosphorylation of smooth muscle caldesmon by three protein kinases: implication for domain mapping

A V Vorotnikov et al. FEBS Lett. .
Free article

Abstract

Phosphorylation of duck gizzard caldesmon by Ca2+/phospholipid-dependent protein kinase, Ca2+/calmodulin-dependent protein kinase and casein kinase II has been investigated. The Ca2+/phospholipid-dependent protein kinase incorporates more than 3 mol phosphate per mol (140 kDa) caldesmon. All phosphorylation sites are localized in the actin- and calmodulin-binding peptide (40-45 kDa) supposed to be a part of the C-terminal domain of caldesmon. Casein kinase II phosphorylates only one site located in a short (25-27 kDa) peptide, presumably in the caldesmon N-terminal domain. The Ca2+/calmodulin-dependent protein kinase phosphorylates two sites located in the N- and C-terminal domains of caldesmon.

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