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Randomized Controlled Trial
. 2020 Jan;29(1):76-85.
doi: 10.1002/pon.5267. Epub 2019 Nov 12.

Randomised controlled trial of internet-delivered cognitive behaviour therapy for clinical depression and/or anxiety in cancer survivors (iCanADAPT Early)

M J Murphy  1 , J M Newby  1   2 , P Butow  3 , S A Loughnan  1 , A E Joubert  1 , L Kirsten  3   4 , K Allison  3 , J Shaw  3 , H L Shepherd  3 , J Smith  1 , G Andrews  1
Affiliations
Randomized Controlled Trial

Randomised controlled trial of internet-delivered cognitive behaviour therapy for clinical depression and/or anxiety in cancer survivors (iCanADAPT Early)

M J Murphy et al. Psychooncology. 2020 Jan.

Abstract

Purpose: To evaluate internet-delivered cognitive behavioural therapy (iCBT) on clinical depression and/or anxiety, distress, fear of cancer recurrence, and quality of life in cancer survivors.

Methods: Random assignation of 114 participants to iCBT or treatment-as-usual (TAU). The clinician-supervised iCBT program (iCanADAPT Early) consisted of eight lessons over 16 weeks. Self-report questionnaires occurred at baseline, midpoint, and posttreatment for both groups with 3-month follow-up for iCBT participants. A mixed modelling approach to compare groups occurred.

Results: iCBT was superior to TAU on all outcome measures at posttreatment. Compared with TAU, the iCBT group showed a significant decrease over time in anxiety and depression symptoms (primary outcome, Hospital Anxiety and Depression Scale, Hedges g = 1.51). Additionally the iCBT group had significantly lower general distress (Kessler-10, g = 1.56), fear of cancer recurrence (Fear of Cancer Recurrence Inventory, g = 0.39), and significantly higher quality of life (Functional Assessment of Cancer Therapy-General, g = 0.74) at posttreatment compared with the TAU group. High adherence and satisfaction were found for iCBT with low clinician time.

Conclusion: Clinician-supervised iCBT has significant benefits for cancer survivors with clinical depression and anxiety disorders.

Keywords: Internet cognitive behavioural therapy; anxiety; cancer; depression; oncology; randomised controlled trial.

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References

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