Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Oct 29;19(1):389.
doi: 10.1186/s12887-019-1762-6.

Clinical findings in congenital infection by Zika virus: a retrospective study in a reference hospital in Central-West Brazil

Cláudia de Paula Guimarães  1 , Myrella Silveira Macedo  2 , Maria Alves Barbosa  3 , Solomar Martins Marques  4 , Paulo Sucasas Costa  4 , Ênio Chaves de Oliveira  4
Affiliations

Clinical findings in congenital infection by Zika virus: a retrospective study in a reference hospital in Central-West Brazil

Cláudia de Paula Guimarães et al. BMC Pediatr. .

Abstract

Background: An increased number of congenital Zika virus infections with neurological and musculoskeletal malformations have been diagnosed worldwide, however, there are still several gaps in the knowledge about this infection, its associated mechanism, timing of transmission, and description of throughout findings of signs and symptoms, which is described in this paper. The purpose of this study is to describe aspects of congenital Zika syndrome (CZS) beyond the central nervous system comprising detailed delineation of all the other clinical findings.

Methods: A retrospective research developed using electronic medical records. We analyzed the files of 69 children with an initial diagnosis of microcephaly by Zika vírus who were born in 2015, 2016 and 2017, treated during the period from 2016 to 2017.

Results: The newborns presented several neurological and musculoskeletal malformations, eye damage, hearing impairment and other malformations.

Conclusions: The present study has significant impact for health care teams following lactents with Congenital Zika Syndrome.

Keywords: Malformations; Microcephaly; Zika virus.

PubMed Disclaimer

Conflict of interest statement

All authors declare no conflicts of interest. In addition, the authors did not receive any fees, grant, or other form of payment to produce this manuscript.

Figures

Fig. 1
Fig. 1
Distribution of clinical finding of Zika virus congenital syndrome
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

  • Heterogeneous development of children with Congenital Zika Syndrome-associated microcephaly.
    Aguilar Ticona JP, Nery N Jr, Doss-Gollin S, Gambrah C, Lessa M, Rastely-Júnior V, Matos A, de Paula Freitas B, Borja A, Wunder EA Jr, Ballalai V, Vieira C, Cruz JS, de Oliveira D, Araujo DB, Oliveira DB, Nascimento Fabris Maeda DL, Mendes EA, Pereira Soares C, Durigon EL, de Souza Ferreira LC, Belfort R, P Almeida AR, Oliveira-Filho J, Reis MG, Ko AI, Costa F. Aguilar Ticona JP, et al. PLoS One. 2021 Sep 15;16(9):e0256444. doi: 10.1371/journal.pone.0256444. eCollection 2021. PLoS One. 2021. PMID: 34525107 Free PMC article.
  • Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review.
    do Amaral YNDV, Malacarne J, Brandão PG, Brasil P, Nielsen-Saines K, Moreira MEL. do Amaral YNDV, et al. Front Psychiatry. 2021 Aug 30;12:699115. doi: 10.3389/fpsyt.2021.699115. eCollection 2021. Front Psychiatry. 2021. PMID: 34526920 Free PMC article.
  • Pathophysiology and mechanisms of hearing impairment related to neonatal infection diseases.
    Capra D, DosSantos MF, Sanz CK, Acosta Filha LG, Nunes P, Heringer M, Ximenes-da-Silva A, Pessoa L, de Mattos Coelho-Aguiar J, da Fonseca ACC, Mendes CB, da Rocha LS, Devalle S, Niemeyer Soares Filho P, Moura-Neto V. Capra D, et al. Front Microbiol. 2023 Apr 14;14:1162554. doi: 10.3389/fmicb.2023.1162554. eCollection 2023. Front Microbiol. 2023. PMID: 37125179 Free PMC article. Review.

References

    1. World Health Organization WHO / Zika situation report – World Health Organization. https://www.who.int/emergencies/zika-virus/situation-report/en/. Acesso em: ago 2019.
    1. Icheky V. A review of the evidence linking Zika virus to the developmental abnormalities that Lead to microcephaly in view of recent Casees of birth defects in Africa. Journal of MPE Molecular Pathological Epidemiologçy, Vol. 2 N. S1:01, 2017.
    1. Blohm Gabriela M, Lednicky John A, Márquez Marilianna, White Sarah K, Loeb Julia C, Pacheco Carlos A, Nolan David J, Paisie Taylor, Salemi Marco, Rodríguez-Morales Alfonso J, Glenn Morris J, Pulliam Juliet R C, Paniz-Mondolfi Alberto E. Evidence for Mother-to-Child Transmission of Zika Virus Through Breast Milk. Clinical Infectious Diseases. 2017;66(7):1120–1121. doi: 10.1093/cid/cix968. - DOI - PMC - PubMed
    1. Seferovic M, Martín CS, Tardif SD. Experimental Zika Virus Infection in the Pregnant Common Marmoset Induces Spontaneous Fetal Loss and Neurodevelopmental Abnormalities. Sci Rep. 2018;8(1):6851. doi: 10.1038/s41598-018-25205-1. - DOI - PMC - PubMed
    1. Santa Rita TH, Barra RB, Peixoto GP, Mesquita PG, Barra GB. Association between suspected Zika virus disease during pregnancy and giving birth to a newborn with congenital microcephaly: a matched case-control study. BMC Res Notes. 2017;10(1):457. doi: 10.1186/s13104-017-2796-1. - DOI - PMC - PubMed