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Editorial
. 2020 Jan 15;201(2):130-132.
doi: 10.1164/rccm.201910-2005ED.

Recruiting the Acutely Injured Lung: How and Why?

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Editorial

Recruiting the Acutely Injured Lung: How and Why?

Luciano Gattinoni et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Schematic representation of the gas-mass redistribution within the lungs after an increase of positive end-expiratory pressure (PEEP) from 5 cm H2O (darker blue, left) to 15 cm H2O (lighter blue, right). On the right, we show the histogram related to the quantitative analysis of the computed tomography (CT) scan in the two conditions. Although we observe a very minor increase in gas volume in the poorly aerated compartments, we observe a significant amount of gas volume increase in the normally and hyperinflated lung compartments. The gas-based method includes a portion of the gas present in the already aerated compartment as a recruited volume. In contrast, the CT scan–based method considers recruitment to be the difference in nonaerated tissue (0/−200 HU, dark blue, dependent) between 5 and 15 cm H2O. The method difference leads to large differences in the recruitment computation.

Comment on

References

    1. Falke KJ, Pontoppidan H, Kumar A, Leith DE, Geffin B, Laver MB. Ventilation with end-expiratory pressure in acute lung disease. J Clin Invest. 1972;51:2315–2323. - PMC - PubMed
    1. Suter PM, Fairley B, Isenberg MD. Optimum end-expiratory airway pressure in patients with acute pulmonary failure. N Engl J Med. 1975;292:284–289. - PubMed
    1. Jardin F, Vieillard-Baron A. Right ventricular function and positive pressure ventilation in clinical practice: from hemodynamic subsets to respirator settings. Intensive Care Med. 2003;29:1426–1434. - PubMed
    1. Tremblay L, Valenza F, Ribeiro SP, Li J, Slutsky AS. Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest. 1997;99:944–952. - PMC - PubMed
    1. Lachmann B. Open up the lung and keep the lung open. Intensive Care Med. 1992;18:319–321. - PubMed