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. 2019;8(1):1546-1549.
doi: 10.1080/22221751.2019.1681242.

Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017-2018

Qianqin Yuan  1 , Yamei Li  2 , Leshan Xiu  2 , Chi Zhang  2 , Yaoyang Fu  1 , Chuanhao Jiang  1 , Lingli Tang  1 , Junping Peng  2
Affiliations

Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017-2018

Qianqin Yuan et al. Emerg Microbes Infect. 2019.

Abstract

The growing multidrug-resistant Neisseria gonorrhoeae is a serious global threat to gonococcal therapy. During 2017-2018, we identified a rare multidrug-resistant (ceftriaxone and azithromycin) strain (GC250) and four strains (GC185, GC195, GC196 and GC249) with both resistance to ceftriaxone and decreased susceptibility to azithromycin. All strains belonged to NG-STAR ST1143, including the mosaic penA-60.001, which is closely related to ceftriaxone resistance. The characterization of antimicrobial resistance (AMR) determinants and phylogenetic analysis showed these five strains were closely related to internationally spreading ceftriaxone-resistant N. gonorrhoeae FC428, but with higher azithromycin MIC. Findings here demonstrated that this clone not only initiated clonal expansion in China, but acquired azithromycin resistance.

Keywords: Neisseria gonorrhoeae; azithromycin; ceftriaxone; multidrug-resistant; phylogeny.

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Conflict of interest statement

No potential conflict of interest was reported by the authors.

Figures

Figure 1.
Figure 1.
Maximum-likelihood tree based on 14965 genome-wide SNP sites. Strains shaded in green are isolates characterized in this study. Circle and star represent the susceptibility to ceftiaxone and azithromycin respectively. The scale is in the units of mutations per site.
See this image and copyright information in PMC

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