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. 2019 Oct 1;60(13):4489-4495.
doi: 10.1167/iovs.19-28632.

The Eye Sees Eye to Eye With the Immune System: The 2019 Proctor Lecture

Jerry Y Niederkorn  1
Affiliations

The Eye Sees Eye to Eye With the Immune System: The 2019 Proctor Lecture

Jerry Y Niederkorn. Invest Ophthalmol Vis Sci. .
No abstract available

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Figures

Figure 1
Figure 1
Dissipation of corneal nerves 24 hours after trephining the mouse cornea. (A) Corneal nerves in untreated BALB/c mouse eye were stained with anti-β tubulin III antibody (green). (B) Dissipation of corneal nerves 24 hours after placing a shallow circular incision in the corneal epithelium using a 2.0-mm trephine.
Figure 2
Figure 2
Severing corneal nerves leads to the generation of contrasuppressor cells that disable T regulatory cells. (A) MHC class II+ DCs reside in the corneal epithelial layer in the limbus. (B) Orthotopic corneal allografts are transplanted in close proximity to CD11c+ DCs in the limbus. (C) Ablating corneal nerves with a trephine leads to the release of substance P that converts resident CD11c+ DCs to CD11c+ CS cells that elaborate additional SP, which disables CD4+CD25+ Tregs.
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