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Meta-Analysis
. 2020 May;49(5):386-394.
doi: 10.1111/jop.12970. Epub 2019 Nov 16.

Prognostic value of CRTC1-MAML2 translocation in salivary mucoepidermoid carcinoma: Systematic review and meta-analysis

Maria Eduarda Pérez-de-Oliveira  1 , Vivian P Wagner  1 , Anna Luíza Damaceno Araújo  1 , Manoela D Martins  2 , Alan Roger Santos-Silva  1 , Lynne Bingle  3 , Pablo A Vargas  1
Affiliations
Meta-Analysis

Prognostic value of CRTC1-MAML2 translocation in salivary mucoepidermoid carcinoma: Systematic review and meta-analysis

Maria Eduarda Pérez-de-Oliveira et al. J Oral Pathol Med. 2020 May.

Abstract

The presence of the CRTC1-MAML2 translocation has been described in mucoepidermoid carcinoma (MEC) as a predictor of better survival rates. However, the real prognostic value of the translocation has been debated due to recent controversial findings. The aim of this study was to perform a systematic review to understand the prognostic potential of the CRTC1-MAML2 translocation in MEC. An electronic search was carried out using the MEDLINE/PubMed, EMBASE and Scopus databases. Articles that assessed the association between the CRTC1-MAML2 translocation and survival of MEC patients were selected for the systematic review. Ten published articles were included in the qualitative synthesis. The prevalence of the translocation varied from 33.7% to 69.7%. Seven studies observed a significant association between the presence of the CRTC1-MAML2 translocation and a favourable clinical outcome, which could improve disease-free, disease-specific or overall survival. Five studies were included in the quantitative synthesis. Fixed-effects model confirmed that translocation-positive patients have a decreased risk of death (combined odds ratio 0.08, 95% confidence interval - 0.03-0.23, P < .00001). The detection of the CRTC1-MAML2 translocation appears to be useful as a prognostic factor in MEC. However, the level of evidence is not as high as it could be once important limitations were found in the published studies.

Keywords: CRTC1-MAML2; mucoepidermoid carcinoma; prognosis; salivary gland tumours; systematic review.

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References

REFERENCES

    1. Fonseca FP, Carvalho MV, Almeida OP, et al. Clinicopathologic analysis of 493 cases of salivary gland tumors in a Southern Brazilian population. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:230-239.
    1. Almeida-Pinto YD, Costa SFDS, Andrade BAB, et al. t(6;9)(MYB-NFIB) in head and neck adenoid cystic carcinoma: A systematic review with meta-analysis. Oral Dis. 2019;25:1277-1282.
    1. Goode RK, Auclair PL, Ellis GL. Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer. 1998;82:1217-1224.
    1. Bell D, Hanna EY. Salivary gland cancers: biology and molecular targets form therapy. Curr Oncol Rep. 2012;14:166-174.
    1. Vargas PA, Speight PM, Bingle CD, Barret AW, Bingle L. Expression of PLUNC family members in benign and malignant salivary gland tumours. Oral Dis. 2008;14:613-619.