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Randomized Controlled Trial
. 2019 Dec;47(12):6235-6243.
doi: 10.1177/0300060519880760. Epub 2019 Oct 30.

Effect of regional arterial infusion combined with early enteral nutrition on severe acute pancreatitis

Xiaojuan Wang  1 , Jinbu Xu  1 , Jiguang Li  2 , Yajuan Cheng  1 , Lu Liu  1 , Zhiqiang Du  1
Affiliations
Randomized Controlled Trial

Effect of regional arterial infusion combined with early enteral nutrition on severe acute pancreatitis

Xiaojuan Wang et al. J Int Med Res. 2019 Dec.

Abstract

Objective: To measure the therapeutic effects of regional arterial infusion (RAI) in combination with early enteral nutrition (EEN) in patients with severe acute pancreatitis (SAP).

Methods: A prospective randomized controlled study enrolled patients with SAP. They were randomly divided into a conventional treatment group that served as the control and a combination therapy group that received RAI combined with EEN. The Acute Physiology, Age, Chronic Health Evaluation II (APACHE II) scores, the levels of serum biochemical indices, functional recovery, the incidence of complications and total effectiveness rate were evaluated.

Results: A total of 100 patients were enrolled in the study. The APACHE II scores and the concentrations of blood glucose, serum amylase, white blood cell count, C-reactive protein, tumour necrosis factor-α, interleukin (IL)-6, IL-10 and IL-17 were significantly decreased, while albumin and serum calcium and total effectiveness rate in the combination therapy group were significantly higher than in the conventional treatment group. The combination therapy group had a significantly reduced time to abdominal pain relief, time of first defaecation, hospital stay and incidence of complications compared with the conventional treatment group.

Conclusion: The combination of RAI and EEN improved clinical biochemical indices, reduced the incidence of complications and promoted early recovery in patients with SAP.

Keywords: Early enteral nutrition; regional arterial infusion; severe acute pancreatitis.

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References

    1. Abbasi AH, Abid S, Pal I, et al. To evaluate the outcomes of drug associated acute pancreatitis and to compare with gall stone and alcohol induced acute pancreatitis. Journal of Pioneering Medical Sciences 2016; 6: 12.
    1. Stefanutti C, Labbadia G, Morozzi C. Severe hypertriglyceridemia-related acute pancreatitis. Ther Apher Dial 2013; 17: 130–137. - PubMed
    1. Mifkovic A, Skultety J, Pindak D, et al. Specific aspects of acute pancreatitis. Bratisl Lek Listy 2009; 110: 544–552. - PubMed
    1. Luque-de León E, Mier-y-Díaz J, Rodríguez-Jerkov J, et al. Dynamic pancreatography: the diagnosis of pancreatic necrosis and the identification of the risk factors of severity. Gac Med Mex 2000; 136: 113–122 [Article in Spanish, English abstract]. - PubMed
    1. Zerem E. Treatment of severe acute pancreatitis and its complications. World J Gastroenterol 2014; 20: 13879–13892. - PMC - PubMed

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