Epigenetic targeting of DNA repair in lung cancer
- PMID: 31662477
- PMCID: PMC6842636
- DOI: 10.1073/pnas.1916581116
Epigenetic targeting of DNA repair in lung cancer
Conflict of interest statement
Competing interest statement: C.M.R. has consulted regarding cancer drug development with AbbVie, Amgen, Ascentage, Bicycle, Celgene, Daiichi Sankyo, Genentech/Roche, Ipsen, Loxo, and PharmaMar, and serves on the SAB of Bridge Medicines and Harpoon Therapeutics.
Comment on
-
DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation.Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22609-22618. doi: 10.1073/pnas.1903765116. Epub 2019 Oct 7. Proc Natl Acad Sci U S A. 2019. PMID: 31591209 Free PMC article.
References
-
- Siegel R. L., Miller K. D., Jemal A., Cancer statistics, 2019. CA Cancer J. Clin. 69, 7–34 (2019). - PubMed
-
- Canadian Cancer Statistics Advisory Committee , Canadian Cancer Statistics 2019 (Canadian Cancer Society, 2019).
-
- Antonia S. J., et al. ; PACIFIC Investigators , Overall survival with durvalumab after chemoradiotherapy in stage III NSCLC. N. Engl. J. Med. 379, 2342–2350 (2018). - PubMed
-
- Bradley J. D., et al. , Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): A randomised, two-by-two factorial phase 3 study. Lancet Oncol. 16, 187–199 (2015). - PMC - PubMed
-
- Raben D., et al. , Patterns of disease progression with durvalumab in stage III non-small cell lung cancer (PACIFIC). Intl. J. Rad. Oncol. Biol. Phys. 105, 683 (2019).
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
