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. 2019 Oct 1:2019:8517371.
doi: 10.1155/2019/8517371. eCollection 2019.

High Recurrence Rate of Myxofibrosarcoma: The Effect of Radiotherapy Is Not Clear

Hjalmar Teurneau  1 , Jacob Engellau  2 , Iman Ghanei  1 , Fredrik Vult von Steyern  1 , Emelie Styring  1
Affiliations

High Recurrence Rate of Myxofibrosarcoma: The Effect of Radiotherapy Is Not Clear

Hjalmar Teurneau et al. Sarcoma. .

Abstract

Background: Myxofibrosarcoma (MFS) is one of the more common types of soft-tissue sarcoma (STS) in patients over 60 years of age. Local recurrence (LR) rates have been reported to be higher compared to other STS types.

Patients and methods: Using a population-based series from the southern Sweden health care region, 56 consecutive patients with MFS and localized disease at diagnosis were analyzed with respect to LR and distant metastases after surgery ± adjuvant treatment.

Results: The overall local recurrence (n = 15) and metastasis (n = 13) rates were 27% and 21%, respectively; 6 patients had both. Surgical margin was the only statistically significant prognostic factor for LR. Patients operated with a marginal margin had an HR of 4.5 (CI 1.3-15.1, p=0.02) and those operated with an intralesional margin 9.4 (CI 2.0-43.5, p=0.004) compared to those operated with a wide surgical margin. There was no difference in the LR rate depending on radiotherapy or not, although the latter group had smaller and more superficial tumors. 23 patients received radiotherapy, 9 of whom developed LR, all within the irradiated field. A tumor size >5 cm and intralesional surgical margin were shown to be risk factors for distant metastases.

Conclusions: The rate of LR for patients with myxofibrosarcoma was high. The impact of RT on local tumor control was unclear. The surgical margin was important for both local and distant tumor control. Large tumor size was a risk factor for distant metastasis.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this article.

Figures

Figure 1
Figure 1
Kaplan–Meier curve illustrating time to local recurrence among all MFSs.
Figure 2
Figure 2
Kaplan–Meier curve illustrating time to metastasis among high-grade MFSs.
See this image and copyright information in PMC

References

    1. Sambri A., Bianchi G., Righi A., Ferrari C., Donati D. Surgical margins do not affect prognosis in high grade myxofibrosarcoma. European Journal of Surgical Oncology (EJSO) 2016;42(7):1042–1048. doi: 10.1016/j.ejso.2016.05.015. - DOI - PubMed
    1. Engellau J., Bendahl P., Persson A., et al. Improved prognostication in soft tissue sarcoma: independent information from vascular invasion, necrosis, growth pattern, and immunostaining using whole-tumor sections and tissue microarrays. Human Pathology. 2005;36(9):994–1002. doi: 10.1016/j.humpath.2005.07.008. - DOI - PubMed
    1. Fletcher C. D. M., Bridge J. A., Hogendoorn P. C. W., Mertens F. World Health Organization Classification of Tumours. 4th. Lyon, France: IARC Press; 2013. WHO classification of tumours of soft tissue and bone.
    1. Mentzel T., Calonje E., Wadden C., et al. Myxofibrosarcoma. The American Journal of Surgical Pathology. 1996;20(4):391–405. doi: 10.1097/00000478-199604000-00001. - DOI - PubMed
    1. Lin C.-N., Chou S.-C., Li C.-F., et al. Prognostic factors of myxofibrosarcomas: implications of margin status, tumor necrosis, and mitotic rate on survival. Journal of Surgical Oncology. 2006;93(4):294–303. doi: 10.1002/jso.20425. - DOI - PubMed

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