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Review
. 2019 Oct 16;5(10):eaax1532.
doi: 10.1126/sciadv.aax1532. eCollection 2019 Oct.

The treatment of cocaine use disorder

Kyle M Kampman  1
Affiliations
Review

The treatment of cocaine use disorder

Kyle M Kampman. Sci Adv. .

Abstract

Cocaine use continues to be a serious worldwide public health problem. Cocaine abuse is associated with substantial morbidity and mortality. Cocaine overdose deaths are increasing in the United States and, in certain populations, outnumber heroin and opiate overdose deaths. Psychosocial treatments remain the treatments of choice for cocaine use disorder (CUD), with standard approaches including contingency management and cognitive behavioral therapy. However, the effect sizes of these treatments are not large, and they are not effective for most patients. Consequently, investigators have sought to develop pharmacological agents to augment the efficacy of psychosocial treatments. Despite these efforts, no medications have yet been proven to be safe and effective for the treatment of CUD. The most promising pharmacological strategies for CUD treatment thus far include the use of dopamine agonists, such as long-acting amphetamine and modafinil or glutamatergic and GABAergic agents such as topiramate. Combination drugs may be especially promising.

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References

    1. Substance Abuse and Mental Health Services Administration (2018). Key Substance Use and Mental Health Indicators in the United States: Results from the 2017 National Survey on Drug Use and Health (HHS Publication No. SMA 18–5068, NSDUH Series H-53), Rockville, MD: Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration; https://www.samhsa.gov/data/.
    1. Butler A. J., Rehm J., Fischer B., Health outcomes associated with crack-cocaine use: Systematic review and meta-analyses. Drug Alcohol Depend. 180, 401–416 (2017). - PubMed
    1. Hedegaard H., Bastian B. A., Trinidad J. P., Spencer M., Warner M., Drugs most frequently involved in drug overdose deaths: United States, 2011-2016. Natl. Vital Stat. Rep. 67, 1–14 (2018). - PubMed
    1. Shiels M. S., Freedman N. D., Thomas D., Berrington de Gonzalez A., Trends in U.S. drug overdose deaths in non-Hispanic black, Hispanic, and non-Hispanic white persons, 2000-2015. Ann. Intern. Med. 168, 453–455 (2018). - PMC - PubMed
    1. Alterman A. I., O'Brien C. P., McLellan A. T., August D. S., Snider E. C., Droba M., Cornish J. W., Hall C. P., Raphaelson A. H., Schrade F. X., Effectiveness and costs of inpatient versus day hospital cocaine rehabilitation. J. Nerv. Ment. Dis. 182, 157–163 (1994). - PubMed