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Review
. 2020 May;235(5):4146-4152.
doi: 10.1002/jcp.29333. Epub 2019 Oct 29.

Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma

Farzad Rahmani  1 , Aghigh Ziaeemehr  2 , Soodabeh Shahidsales  3 , Masoumeh Gharib  4 , Majid Khazaei  5 , Gordon A Ferns  6 , Mikhail Ryzhikov  7 , Amir Avan  8   9 , Seyed M Hassanian  1   8
Affiliations
Review

Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma

Farzad Rahmani et al. J Cell Physiol. 2020 May.

Abstract

Hepatocellular carcinoma (HCC) is one of the common malignant human tumors with high morbidity worldwide. Aberrant activation of the oncogenic phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling is related to clinicopathological features of HCC. Emerging data revealed that microRNAs (miRNAs) have prominent implications for regulating cellular proliferation, differentiation, apoptosis, and metabolism through targeting the PI3K/AKT/mTOR signaling axis. The recognition of the crucial role of miRNAs in hepatocarcinogenesis represents a promising area to identify novel anticancer therapeutics for HCC. The present study summarizes the major findings about the regulatory role of miRNAs in the PI3K/AKT/mTOR pathway in the pathogenesis of HCC.

Keywords: PI3K/AKT/mTOR pathway; hepatocellular carcinoma; microRNA.

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