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. 2019 Dec;13(18):1577-1588.
doi: 10.2217/bmm-2019-0124. Epub 2019 Oct 30.

Interleukins and miRNAs intervene in the early stages of diabetic kidney disease in Type 2 diabetes mellitus patients

Ligia Petrica  1   2 , Oana Milas  1 , Mihaela Vlad  3 , Adrian Vlad  4 , Florica Gadalean  1 , Victor Dumitrascu  5 , Silvia Velciov  1 , Cristina Gluhovschi  1 , Flaviu Bob  1 , Sorin Ursoniu  2   6 , Dragos C Jianu  7 , Petru Matusz  8 , Agneta-Maria Pusztai  8 , Octavian Cretu  9 , Daniela Radu  10 , Alina Secara  1 , Anca Simulescu  1 , Maria Stefan  1 , Roxana Popescu  11 , Daliborca Vlad  5
Affiliations

Interleukins and miRNAs intervene in the early stages of diabetic kidney disease in Type 2 diabetes mellitus patients

Ligia Petrica et al. Biomark Med. 2019 Dec.

Abstract

Aim: The involvement of proinflammatory interleukins (IL) in diabetic kidney disease of Type 2 diabetes mellitus (DM) patients was studied in relation to a particular miRNA profile. Materials & methods: A total of 117 patients with Type 2 DM and 11 controls were enrolled in a case series study. Serum and urinary ILs and miRNAs were assessed. Results: IL-1α correlated with miRNA21, 124, estimated glomerular filtration rate (eGFR) and negatively with miRNA125a and 192; IL-8 with miRNA21, 124, eGFR and negatively with miRNA125a, 126 and 146a; IL-18 with miRNA21, 124 and negatively with miRNA146a, 192, eGFR. Conclusion: There is an association between specific serum and urinary ILs and serum and urinary miRNAs profiles in the inflammatory response in Type 2 DM patients with diabetic kidney disease.

Keywords: albuminuria; diabetes mellitus; interleukins; miRNAs.

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