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Comment
. 2020 Mar 2;221(6):1025-1026.
doi: 10.1093/infdis/jiz539.

Importance of Study Design and Phenotype Definition in Ongoing Studies of Resistance to Latent Mycobacterium tuberculosis Infection

Affiliations
Comment

Importance of Study Design and Phenotype Definition in Ongoing Studies of Resistance to Latent Mycobacterium tuberculosis Infection

Catherine M Stein et al. J Infect Dis. .
No abstract available

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Figures

Figure 1.
Figure 1.
Quantitative Quantiferon (QFT) values among QFT-positive subjects by tuberculin skin test (TST)-positivity. Boxplots show distributions of QFT-Plus quantitative values in TST-positive (N = 222, TST ≥10-mm induration) and TST-negative (N = 12, TST <10-mm induration) subjects (all human immunodeficiency virus-negative). Comparison of individuals with 0–5 mm versus 5–9.9 mm TST shows similar distributions of interferon (IFN)-gamma values (data not shown). Comparison of quantitative values by Mann-Whitney test, P = .128. Comparison using 4 IU/mL cutoff value as proposed by Andrews et al [9], represented by red line, P = .063.

Comment on

References

    1. Verrall AJ, Alisjahbana B, Apriani L, et al. . Early clearance of Mycobacterium tuberculosis: the INFECT case contact cohort study in Indonesia. J Infect Dis 2019. - PubMed
    1. Ma N, Zalwango S, Malone LL, et al. ; Tuberculosis Research Unit (TBRU) Clinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Uganda. BMC Infect Dis 2014; 14:352. - PMC - PubMed
    1. Stein CM, Nsereko M, Malone LL, et al. . Long-term stability of resistance to latent Mycobacterium tuberculosis infection in highly exposed tuberculosis household contacts in Kampala, Uganda. Clin Infect Dis 2019; 68:1705–12. - PMC - PubMed
    1. Stein CM, Zalwango S, Malone LL, et al. . Resistance and susceptibility to Mycobacterium tuberculosis infection and disease in tuberculosis households in Kampala, Uganda. Am J Epidemiol 2018; 187:1477–89. - PMC - PubMed
    1. Mave V, Chandrasekaran P, Chavan A, et al. ; CTRIUMPH RePORT India Study Team Infection free “resisters” among household contacts of adult pulmonary tuberculosis. PLoS One 2019; 14:e0218034. - PMC - PubMed