Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Dec 23;58(1):e01446-19.
doi: 10.1128/JCM.01446-19. Print 2019 Dec 23.

One Size Fits All? Application of Susceptible-Dose-Dependent Breakpoints to Pediatric Patients and Laboratory Reporting

Lindsey E Nielsen  1 , Jeanne B Forrester  2 , Jennifer Ellis Girotto  3   4 , Aimee M Dassner  5 , Romney Humphries  6
Affiliations
Review

One Size Fits All? Application of Susceptible-Dose-Dependent Breakpoints to Pediatric Patients and Laboratory Reporting

Lindsey E Nielsen et al. J Clin Microbiol. .

Abstract

The Clinical and Laboratory Standards Institute antimicrobial and antifungal standards define a susceptible-dose-dependent (SDD) category for certain organisms and drug combinations. Reporting MICs within the SDD category suggests that treatment success is likely with increased drug exposure. These breakpoints are based on pharmacokinetic, pharmacodynamic, and clinical outcome data from adults and not pediatric patients. This commentary aims to discuss the implications of reporting SDD interpretations for pediatric patients and recommends laboratory reporting comments.

Keywords: CLSI; M100; M40; MIC; antimicrobial agents; breakpoints; pediatric drug therapy; susceptible-dose dependent.

PubMed Disclaimer

References

    1. CLSI. 2019. Performance standards for antimicrobial susceptibility testing, 29th ed CLSI supplement M100 Clinical and Laboratory Standards Institute, Wayne, PA.
    1. CLSI. 2017. Performance standards for antifungal susceptibility testing of yeasts, 1st ed Clinical and Laboratory Standards Institute, Wayne, PA.
    1. Baditoiu L, Axente C, Lungeanu D, Muntean D, Horhat F, Moldovan R, Hogea E, Bedreag O, Sandesc D, Licker M. 2017. Intensive care antibiotic consumption and resistance patterns: a cross-correlation analysis. Ann Clin Microbiol Antimicrob 16:71. doi:10.1186/s12941-017-0251-8. - DOI - PMC - PubMed
    1. McLaughlin M, Advincula MR, Malczynski M, Qi C, Bolon M, Scheetz MH. 2013. Correlations of antibiotic use and carbapenem resistance in Enterobacteriaceae. Antimicrob Agents Chemother 57:5131–5133. doi:10.1128/AAC.00607-13. - DOI - PMC - PubMed
    1. Avery LM, Kuti JL, Weisser M, Egli A, Rybak MJ, Zasowski EJ, Arias CA, Contreras GA, Chong PP, Aitken SL. 2018. Pharmacodynamic analysis of daptomycin-treated enterococcal bacteremia: it is time to change the breakpoint. Clin Infect Dis 68:1650–1657. doi:10.1093/cid/ciy749. - DOI - PMC - PubMed

MeSH terms