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. 2019 Jul 25;7(15):2467-2473.
doi: 10.3889/oamjms.2019.664. eCollection 2019 Aug 15.

Association between Dyslipidemia and Peritoneal Dialysis Technique Survival

Natalia Stepanova  1 , Olena Burdeyna  1
Affiliations

Association between Dyslipidemia and Peritoneal Dialysis Technique Survival

Natalia Stepanova et al. Open Access Maced J Med Sci. .

Abstract

Background: A large body of research has investigated the effects of pro-atherogenic lipid profile on cardiovascular diseases (CVD) in peritoneal dialysis (PD) patients. However, there is a general lack of research on the association between atherogenic dyslipidemia and PD technique survival.

Aim: The study aimed to define the association between dyslipidemia and PD technique survival.

Methods: It was a prospective single-centre observational study involving 40 outpatients on continuous ambulatory PD treatment for more than 3 months between 2010 and 2016 in a single centre in Ukraine. There were 27 males and 13 females. The mean age of the participants was 49.3 ± 12.2 years. The primary outcome measures were all-cause technique failure.

Results: Atherogenic dyslipidemia was identified in 28/40 (70 %) patients and correlated with PD adequacy parameters. During the 36-month- follow-up period technique failure occurred in 2/12 (16.6 %) patients with atherogenic dyslipidemia compared with 12 / 28 (42.9 %) patients without atherogenic dyslipidemia (χ2 = 2.5; p = 0.12). In the univariate Cox regression model, atherogenic dyslipidemia at baseline was significantly associated with a higher risk of all-cause PD technique failure (HR 4.5; 95% CI 1.6 to 12.9; χ2 = 5.5, p = 0.019).

Conclusion: The presence of atherogenic dyslipidemia was significantly associated with a higher risk of technique failure in PD patients. This is an important issue for future research. Further well-designed clinical trials are needed to determine the impact of dyslipidemia on PD adequacy and technique survival.

Keywords: Atherogenic dyslipidemia; PD adequacy; Peritoneal dialysis; Technique failure; Technique survival.

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Figures

Figure 1
Figure 1
The correlation between AIP level and duration of PD treatment in PD patients
Figure 2
Figure 2
The correlation between HDL levels and total weekly Kt / V in PD patients
Figure 3
Figure 3
The incidence of all-cause PD technique failure stratified according to atherogenic dyslipidemia status
Figure 4
Figure 4
The Kaplan-Meier technique survival curves in PD patients dichotomised according to atherogenic dyslipidemia status
See this image and copyright information in PMC

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