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Review
. 2019 Sep 25;4(3):20190024.
doi: 10.1515/pp-2019-0024. eCollection 2019 Sep 1.

Multicystic peritoneal mesothelioma: a systematic review of the literature

Barbara Noiret  1 , Florence Renaud  2   3   4 , Guillaume Piessen  1   2   3 , Clarisse Eveno  1   2   3
Affiliations
Review

Multicystic peritoneal mesothelioma: a systematic review of the literature

Barbara Noiret et al. Pleura Peritoneum. .

Abstract

Multicystic peritoneal mesothelioma (MCPM) is a particularly rare and benign neoplasm that arises from the peritoneum in reproductive aged females. Its etiopathogenesis is still unclear. The current prevailing theory supports the idea that the tumor is the result of an excessive inflammatory process. Because of a lack of clinical and imaging presentation, the diagnosis is intricate, and heavily relies on case reports and short studies. A histological analysis with immunohistochemistry is required for a definitive diagnosis. To date, there is no standard treatment recommended for MCPM. However, some studies suggest proceeding with a cytoreductive surgery and a hyperthermic intraperitoneal chemotherapy combining CISPLATIN and DOXORUBICIN, due to a high incidence of recurrence rate after medical treatment or surgery alone and potential malignant transformation.

Keywords: cytoreductive surgery; diagnosis; hyperthermic intraperitoneal chemotherapy; multicystic peritoneal mesothelioma; pathogenesis.

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Conflict of interest statement

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Figures

Figure 1:
Figure 1:
Multicystic mass (star) located in the pelvis with a decreased signal on T1-weighted image (A) but an increased signal intensity on T2-weighted image (B).
Figure 2:
Figure 2:
Multicystic mass is composed of multiple translucent cysts gathered in a grape-like form (A), filled with serous fluid, hemorrhagic or gelatinous materials. Multicystic in douglas pouch (star), adherent to the rectum (arrow).
Figure 3:
Figure 3:
Anatomopathologic aspects of MCPM (x 1) with HES (A). The cystic lesions are lined by a single layer of flattened or cuboidal (arrow) regular mesothelial cells (B). The cells were relatively immunohistochemically positive for calretinin (C) and negative for CD34 (D).
See this image and copyright information in PMC

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