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Review
. 2019 Aug 7;3(9):e10213.
doi: 10.1002/jbm4.10213. eCollection 2019 Sep.

microRNA-Mediated Regulation of Bone Remodeling: A Brief Review

Jin Liu  1 , Lei Dang  1 , Xiaohao Wu  1 , Dijie Li  1   2 , Qing Ren  1 , Aiping Lu  1 , Ge Zhang  1
Affiliations
Review

microRNA-Mediated Regulation of Bone Remodeling: A Brief Review

Jin Liu et al. JBMR Plus. .

Abstract

microRNA (miRNA)-mediated regulation represents a highly efficient posttranscriptional mechanism for controlling intracellular protein expression. In the past decade, many studies have shown that various miRNAs are involved in regulating bone remodeling by affecting different stages of osteoblastogenesis, osteocytic differentiation, and osteoclastogenesis to govern osteoblastic bone formation and osteoclastic bone resorption. Moreover, miRNAs are recently implicated in mediating the cell-cell communications among bone cells. This review concentrates on the miRNA-mediated regulatory mechanisms of osteoblasts, osteoclasts, and osteocytes, and their contribution to bone remodeling. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

Keywords: BONE MODELING AND REMODELING; MICRO RNA; OSTEOBLASTS; OSTEOCLASTS; OSTEOCYTES.

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Figures

Figure 1
Figure 1
Schematic diagram of the key miRNA players in osteoblast differentiation, osteoclast differentiation, and osteoblast‐osteoclast crosstalk. Red lines ending with a short perpendicular line indicate that miRNA‐mediated regulation upregulates the osteoblast/osteoclast differentiation and activity. Black lines ending with a short perpendicular line indicate that miRNA‐mediated regulation downregulates the osteoblast/osteoclast differentiation and activity.
See this image and copyright information in PMC

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