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. 2019 Oct 30;3(1):66.
doi: 10.1186/s41687-019-0154-x.

A qualitative study exploring the health-related quality of life and symptomatic experiences of adults and adolescents with ulcerative colitis

Louise Newton  1 , Jason A Randall  2 , Theresa Hunter  3 , Shannon Keith  4 , Tara Symonds  1 , Roberta J Secrest  3 , Wendy J Komocsar  3 , Sarah E Curtis  3 , Linda Abetz-Webb  5 , Michael Kappelman  6 , April N Naegeli  3
Affiliations

A qualitative study exploring the health-related quality of life and symptomatic experiences of adults and adolescents with ulcerative colitis

Louise Newton et al. J Patient Rep Outcomes. .

Abstract

Background: Ulcerative colitis (UC) often first presents during adolescence and early adulthood. Primary symptoms of UC are well known, yet similarities and differences of disease experience in adults and adolescents are not well characterized.

Methods: To understand the health-related quality of life (HRQoL) and symptomatic experience of UC, in-depth interviews were conducted in the US with 21 adults (20-70 years) and 14 adolescents (12-17 years). Eligibility and medical history were confirmed by clinician report. A previously conducted literature review and resultant conceptual model informed the discussion guide to explore symptoms and HRQoL. Age appropriate creative tasks ("animal" task and collage) were employed to facilitate discussion. Transcripts and collages were subjected to thematic analysis using ATLAS.ti software.

Results: Clinician-reported UC severity included 24% mild, 38% moderate, 38% severe among adults; and 64% mild, 29% moderate, 7% severe among adolescents. Among adults, 52% were female, 67% were white. Among adolescents, 50% were female, 71% were white. During analysis it was noted that all participants reported stomach/abdominal pain. Other key symptoms identified were frequent bowel movements, diarrhea, blood in stools, sudden need for bowel movement, stomach cramping, bloating, and feeling gassy/passing gas (≥75% of participants). Key impacts identified were embarrassment, dietary limitations, having to plan around UC, worry/fear, anger, low mood/depression, and relationship with others, (≥75% of participants). In creative tasks, animals were chosen to represent their UC and content included in the collages reflected the most commonly discussed themes from the interviews. Only adults discussed feeling dehydrated, while only adolescents discussed the impact of UC on school life.

Conclusions: Open-ended interviews highlighted the HRQoL and symptomatic experiences of UC from the patient's perspective, which were similar between adult and adolescent UC patients.

Keywords: Adolescent; Adult; Experience; Qualitative; Ulcerative colitis.

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Conflict of interest statement

Theresa Hunter, Roberta J. Secrest, Wendy J. Komocsar, Sarah E. Curtis, and April N. Naegeli are employees of Eli-Lilly and Company who provided financial support for this study. Linda Abetz-Webb and Michael Kappelman are consultants who provided insight and feedback on the study. Louise Newton, Jason A. Randall, Shannon Keith, and Tara Symonds are employees of Clinical Outcomes Solutions, who designed and undertook this research.

Figures

Fig. 1
Fig. 1
Example of a participant’s collage from this study
Fig. 2
Fig. 2
Revised conceptual model of adult and adolescent UC symptoms and HRQoL impacts
See this image and copyright information in PMC

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