Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Nov;74(5):724-725.
doi: 10.1016/j.annemergmed.2019.05.033.

Andexanet Response

Truman J Milling Jr  1 , Stuart Connolly  2
Affiliations
Comment

Andexanet Response

Truman J Milling Jr et al. Ann Emerg Med. 2019 Nov.
No abstract available

PubMed Disclaimer

Comment in

  • In reply.
    Radecki RP, Spiegel RJ, Wang HE. Radecki RP, et al. Ann Emerg Med. 2019 Nov;74(5):727. doi: 10.1016/j.annemergmed.2019.05.035. Ann Emerg Med. 2019. PMID: 31668250 No abstract available.

Comment on

References

    1. Radecki RP, Spiegel RJ. Adventures with andexanet alfa in efficacy, effectiveness, and one-armed studies: May 2019 Annals of Emergency Medicine Journal Club. Ann Emerg Med. 2019;73:545–547. - PMC - PubMed
    1. Siegal DM, Curnutte JT, Connolly SJ, et al. Andexanet alfa for the reversal of factor Xa inhibitor activity. N Engl J Med. 2015;373:2413–2424. - PubMed
    1. Lu G, Hollenbach DC, Baker S, et al. Preclinical safety and efficacy of andexanet alpha in animal models. J Thromb Haemost. 2017;15:1747–1756. - PubMed
    1. van Ryn J, Litzenburger T, Schurer J. Reversal of anticoagulant activity of dabigatran and dabigatran-induced bleeding in rats by a specific antidote (antibody fragment). Circulation. 2012;126:A9928.
    1. Glund S, Moschetti V, Norris S, et al. A randomised study in healthy volunteers to investigate the safety, tolerability and pharmacokinetics of idarucizumab, a specific antidote to dabigatran. Thromb Haemost. 2015;113:943–951. - PubMed