Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 May;15(5):646-50.
doi: 10.1128/AAC.15.5.646.

In vitro antibacterial activity and beta-lactamase stability of SCE-129, a new cephalosporin

H C Neu, K P Fu

In vitro antibacterial activity and beta-lactamase stability of SCE-129, a new cephalosporin

H C Neu et al. Antimicrob Agents Chemother. 1979 May.

Abstract

SCE-129 [3-4-carbamoyl-1-pyridiniomethyl-7beta- (d-alpha-sulfophenylacetamido)-ceph-3-em-4-carboxylate] is a cephalosporin that inhibits Pseudomonas aeruginosa and Staphylococcus aureus. SCE-129 is tenfold more active than carbenicillin in inhibiting P. aeruginosa. SCE-129 has poor activity against Enterobacteriaceae compared with other cephalosporins and is 16-fold less active than the cephalosporins against streptococci. The activity of SCE-129 does not correlate with beta-lactamase stability, although SCE-129 is resistant to hydrolysis by gram-positive and gram-negative bacteria. The compound does not inhibit the hydrolysis of other cephalosporins. Although SCE-129 acts synergistically with gentamicin to inhibit some Pseudomonas, this cannot be predicted based on knowledge of resistance to one or more compounds.

PubMed Disclaimer

References

    1. Antimicrob Agents Chemother. 1978 Mar;13(3):536-9 - PubMed
    1. Antimicrob Agents Chemother. 1978 Feb;13(2):137-45 - PubMed
    1. Arch Biochem Biophys. 1970 Aug;139(2):278-90 - PubMed
    1. Antimicrob Agents Chemother. 1979 Feb;15(2):273-81 - PubMed
    1. Infection. 1977;5(4):259-60 - PubMed

LinkOut - more resources