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Comment
. 2019 Dec;44(12):993-995.
doi: 10.1016/j.tibs.2019.10.001. Epub 2019 Oct 23.

Nucleolus: A Protein Quality Control Compartment

Pavani Rekulapally  1 , S N Suresh  2
Affiliations
Comment

Nucleolus: A Protein Quality Control Compartment

Pavani Rekulapally et al. Trends Biochem Sci. 2019 Dec.

Abstract

Frottin et al. uncovered a role for the nucleolus as a key quality control compartment that regulates misfolded nuclear proteins. This nonmembrane compartment achieves this by forming liquid-like protein condensates that aid protein refolding in a heat-shock protein (Hsp)70-dependent manner. This liquid-liquid phase separation (LLPS)-mediated nuclear quality control mechanism is perturbed during neurodegeneration.

Keywords: chaperone-assisted refolding; liquid–liquid phase separation; membraneless compartments; neurodegeneration; nucleolus; nucleophosmin 1.

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