Comment
doi: 10.1016/j.tibs.2019.10.001.
Epub 2019 Oct 23.
Nucleolus: A Protein Quality Control Compartment
Affiliations
- PMID: 31668600
- DOI: 10.1016/j.tibs.2019.10.001
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Comment
Nucleolus: A Protein Quality Control Compartment
Trends Biochem Sci.
2019 Dec.
Abstract
Frottin et al. uncovered a role for the nucleolus as a key quality control compartment that regulates misfolded nuclear proteins. This nonmembrane compartment achieves this by forming liquid-like protein condensates that aid protein refolding in a heat-shock protein (Hsp)70-dependent manner. This liquid-liquid phase separation (LLPS)-mediated nuclear quality control mechanism is perturbed during neurodegeneration.
Keywords: chaperone-assisted refolding; liquid–liquid phase separation; membraneless compartments; neurodegeneration; nucleolus; nucleophosmin 1.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Comment on
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The nucleolus functions as a phase-separated protein quality control compartment.Science. 2019 Jul 26;365(6451):342-347. doi: 10.1126/science.aaw9157. Epub 2019 Jul 11. Science. 2019. PMID: 31296649