Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May;140(5):995-1002.
doi: 10.1016/j.jid.2019.09.016. Epub 2019 Oct 24.

Association between Human Leukocyte Antigen Type and Keratinocyte Carcinoma Risk in Renal Transplant Recipients

Yuhree Kim  1 , David Wojciechowski  2 , Vikram Pattanayak  3 , Hang Lee  4 , Maryam M Asgari  5
Affiliations

Association between Human Leukocyte Antigen Type and Keratinocyte Carcinoma Risk in Renal Transplant Recipients

Yuhree Kim et al. J Invest Dermatol. 2020 May.

Abstract

Keratinocyte carcinoma (KC), defined as squamous cell carcinoma and basal cell carcinoma, is the most common malignancy among white, non-Hispanic renal transplant recipients. Although recent genome-wide association studies reported that class II HLA is associated with KC risk, epidemiologic data on HLA type and KC risk in renal transplant recipients is limited. Using an institutional cohort of white, non-Hispanic renal transplant recipients transplanted between 1993 and 2017, we examined the association between pretransplant molecular HLA types and KC risk. Posttransplant KCs were captured using the International Classification of Diseases codes and validated using pathology reports. Cox proportional hazards regression models were used to estimate hazard ratios of incident KC, squamous cell carcinoma, and basal cell carcinoma, adjusting for age, male sex, history of KC, Charlson comorbidity index, HLA mismatch, transplant type, year of transplant, and the type of immunosuppression. Among 617 subjects (mean age 53 years, 67% male), 10% developed posttransplant KC. Multivariable Cox regression analyses showed HLA-DRB1∗13 was associated with KC risk (hazard ratio, 1.84; 95% confidence interval, 1.00-3.38) and squamous cell carcinoma risk (hazard ratio, 2.24; 95% confidence interval, 1.12-4.49), whereas HLA-DRB1∗14 (hazard ratio, 2.81; 95% confidence interval, 1.14-6.91) was associated with basal cell carcinoma risk. Our findings suggest that a subset of renal transplant recipients with specific HLA polymorphisms may be at increased KC risk.

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST

Dr. Asgari has received institutional grant funding from Pfizer Inc. for unrelated research (involving atopic dermatitis). The remaining authors have to conflict of interest to disclose.

Figures

Figure 1.
Figure 1.. Frequencies of HLA types among white, non-Hispanic renal transplant recipients.
BCC, basal cell carcinoma; SCC, squamous cell carcinoma.
Figure 2.
Figure 2.. Adjusted HRs for HLA and carcinoma risk among white, non-Hispanic renal transplant recipients.
(a) KC risk. (b) SCC risk. (c) BCC risk. BCC, basal cell carcinoma; CI, confidence interval; HR, hazard ratio; KC, keratinocyte carcinoma; SCC, squamous cell carcinoma. * p-value <0.05; 1. All analyses were adjusted for age at transplant, sex, history of KC, Charlson comorbidity index, chronologic year of transplant, HLA mismatch, transplant type and type of immunosuppression. 2. HLA-C was displayed on a Y-axis with different range given wider 95% CI due to small subject number
Figure 2.
Figure 2.. Adjusted HRs for HLA and carcinoma risk among white, non-Hispanic renal transplant recipients.
(a) KC risk. (b) SCC risk. (c) BCC risk. BCC, basal cell carcinoma; CI, confidence interval; HR, hazard ratio; KC, keratinocyte carcinoma; SCC, squamous cell carcinoma. * p-value <0.05; 1. All analyses were adjusted for age at transplant, sex, history of KC, Charlson comorbidity index, chronologic year of transplant, HLA mismatch, transplant type and type of immunosuppression. 2. HLA-C was displayed on a Y-axis with different range given wider 95% CI due to small subject number
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Asgari MM, Wang W, Ioannidis NM, Itnyre J, Hoffmann T, Jorgenson E, et al. Identification of susceptibility loci for cutaneous squamous cell carcinoma. J Invest Dermatol 2016;136:930–7. - PMC - PubMed
    1. Attia EA, El Shennawy D, Sefin A. Serum interleukin-4 and total immunoglobulin E in nonatopic alopecia areata patients and HLA-DRB1 typing. Dermatol Res Pract 2010;2010:503587. - PMC - PubMed
    1. Aureli A, Canossi A, Del Beato T, Franceschilli L, Buonomo O, Papola F, et al. HLA-DRB1*13:01 allele in the genetic susceptibility to colorectal carcinoma. Int J Cancer 2015;136:2464–8. - PubMed
    1. Barrett WL, First MR, Aron BS, Penn I. Clinical course of malignancies in renal transplant recipients. Cancer 1993;72:2186–9. - PubMed
    1. Blomberg M, He SY, Harwood C, Arron ST, Demehri S, Green A, et al. Research gaps in the management and prevention of cutaneous squamous cell carcinoma in organ transplant recipients. Br J Dermatol 2017;177:1225–33. - PMC - PubMed

Publication types