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Case Reports
. 2019 Dec;59(12):3575-3579.
doi: 10.1111/trf.15578. Epub 2019 Oct 31.

Cold reacting anti-M causing delayed hemolytic disease of the newborn

Philip Crispin  1   2   3 , Kelly Sliwinski  1 , Caroline Wilson  2 , Samantha Lennard  1 , Marianne DeSouza  1 , Farah Sethna  4
Affiliations
Case Reports

Cold reacting anti-M causing delayed hemolytic disease of the newborn

Philip Crispin et al. Transfusion. 2019 Dec.

Abstract

Background: Hemolytic disease of the fetus and newborn (HDFN) is due to passively transferred maternal antibodies directed against fetal red blood cell (RBC) antigens and can lead to severe morbidity and mortality. Anti-M is usually a naturally occurring antibody of low clinical significance, although occasionally severe cases of HDFN are seen.

Case reports: Two M+ sisters are presented, each developing hemolysis during the first 2 weeks of life due to maternal anti-M, resulting in severe anemia and requiring blood transfusion. RBC agglutination was observed in peripheral blood samples of both infants at room temperature with dissociation at 37°C. Maternal anti-M detected by column indirect agglutination technique, was of low titer (1:16) and demonstrated low thermal amplitude, reacting in saline at 4°C but was not detectable in saline at 37°C.

Conclusions: Anti-M of low thermal amplitude may cause hemolytic disease of the newborn with laboratory features resembling cold agglutinin disease.

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References

REFERENCES

    1. Makroo RN, Rajput S, Agarwal S, et al. Prevalence of irregular red cell antibody in healthy blood donors attending a tertiary care hospital in North India. Asian J Transfus Sci 2018;12:17-20.
    1. Smith ML, Beck ML. The immunoglobulin structure of human anti-M agglutinins. Transfusion 1979;19:472-4.
    1. Makroo RN, Arora B, Bhatia A, et al. Clinical significance of antibody specificities to M, N and Lewis blood group system. Asian J Transfus Sci 2014;8:96-9.
    1. Smith HM, Shirey RS, Thoman SK, et al. Prevalence of clinically significant red blood cell alloantibodies in pregnant women at a large tertiary-care facility. Immunohematology 2013;29:127-30.
    1. Bollason G, Hjartardottir H, Jonsson T, et al. Red blood cell alloimmunization in pregnancy during the years 1996-2015 in Iceland: a nation-wide population study. Transfusion 2017;57:2578-85.

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