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Review
. 2020 Jan;21(1):13-33.
doi: 10.1111/tra.12710. Epub 2019 Nov 28.

The evolution of the axonal transport toolkit

Sunaina Surana  1 , David Villarroel-Campos  1 , Oscar M Lazo  1   2 , Edoardo Moretto  2 , Andrew P Tosolini  1 , Elena R Rhymes  1 , Sandy Richter  1 , James N Sleigh  1   2 , Giampietro Schiavo  1   2   3
Affiliations
Free article
Review

The evolution of the axonal transport toolkit

Sunaina Surana et al. Traffic. 2020 Jan.
Free article

Abstract

Neurons are highly polarized cells that critically depend on long-range, bidirectional transport between the cell body and synapse for their function. This continual and highly coordinated trafficking process, which takes place via the axon, has fascinated researchers since the early 20th century. Ramon y Cajal first proposed the existence of axonal trafficking of biological material after observing that dissociation of the axon from the cell body led to neuronal degeneration. Since these first indirect observations, the field has come a long way in its understanding of this fundamental process. However, these advances in our knowledge have been aided by breakthroughs in other scientific disciplines, as well as the parallel development of novel tools, techniques and model systems. In this review, we summarize the evolution of tools used to study axonal transport and discuss how their deployment has refined our understanding of this process. We also highlight innovative tools currently being developed and how their addition to the available axonal transport toolkit might help to address key outstanding questions.

Keywords: axonal transport; dynein; imaging; kinesin; mitochondria; signalling endosome.

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References

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