Meta-Analysis

. 2019 Oct 31;16(1):96.

doi: 10.1186/s12966-019-0858-6.

Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry database (ICAD)

Katrien Wijndaele¹, Thomas White², Lars Bo Andersen^{3

4}, Anna Bugge^{5

6}, Elin Kolle⁴, Kate Northstone⁷, Niels Wedderkopp^{3

5}, Mathias Ried-Larsen^{3

5}, Susi Kriemler⁸, Angie S Page⁹, Jardena J Puder¹⁰, John J Reilly¹¹, Luis B Sardinha¹², Esther M F van Sluijs^{2

13}, Stephen J Sharp², Søren Brage², Ulf Ekelund⁴; International Children’s Accelerometry Database (ICAD) Collaborators

Collaborators, Affiliations

Collaborators

International Children’s Accelerometry Database (ICAD) Collaborators:
L B Andersen, S Anderssen, A J Atkin, G Cardon, R Davey, U Ekelund, D W Esliger, P Hallal, B H Hansen, K F Janz, S Kriemler, N Møller, K Northstone, A Page, R Pate, J J Puder, J J Reilly, J Salmon, L B Sardinha, L B Sherar, A Timperio, E M F van Sluijs

Affiliations

¹ MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Box 285, Addenbrooke's Hospital Hills Road Cambridge, Cambridge, CB2 0QQ, UK. katrien.wijndaele@mrc-epid.cam.ac.uk.
² MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Box 285, Addenbrooke's Hospital Hills Road Cambridge, Cambridge, CB2 0QQ, UK.
³ Faculty of Teacher Education and Sport, Campus Sogndal, Western Norway University of Applied Sciences, Bergen, Norway.
⁴ Department of Sport Medicine, Norwegian School of Sport Sciences, Oslo, Norway.
⁵ Centre for Research in Childhood Health, Exercise Epidemiology Unit, Department of Sport Sciences and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
⁶ Physiotherapy, University College Copenhagen, Copenhagen, Denmark.
⁷ Bristol Medical School, University of Bristol, Bristol, UK.
⁸ Institute of Social and Preventive Medicine, University of Zurich, Zürich, Switzerland.
⁹ Centre for Exercise, Nutrition and health Sciences, School for Policy Studies, University of Bristol, Bristol, UK.
¹⁰ Lausanne University Hospital, Lausanne, Switzerland.
¹¹ School of Psychological Sciences and Health, University of Strathclyde, Glasgow, Scotland.
¹² Exercise and Health Laboratory, CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal.
¹³ UKCRC Centre for Diet and Activity Research (CEDAR), University of Cambridge, Cambridge, UK.

PMID: 31672163
PMCID: PMC6822444
DOI: 10.1186/s12966-019-0858-6

Meta-Analysis

Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry database (ICAD)

Katrien Wijndaele et al. Int J Behav Nutr Phys Act. 2019.

. 2019 Oct 31;16(1):96.

doi: 10.1186/s12966-019-0858-6.

Authors

Collaborators

International Children’s Accelerometry Database (ICAD) Collaborators:
L B Andersen, S Anderssen, A J Atkin, G Cardon, R Davey, U Ekelund, D W Esliger, P Hallal, B H Hansen, K F Janz, S Kriemler, N Møller, K Northstone, A Page, R Pate, J J Puder, J J Reilly, J Salmon, L B Sardinha, L B Sherar, A Timperio, E M F van Sluijs

Affiliations

¹ MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Box 285, Addenbrooke's Hospital Hills Road Cambridge, Cambridge, CB2 0QQ, UK. katrien.wijndaele@mrc-epid.cam.ac.uk.
² MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Box 285, Addenbrooke's Hospital Hills Road Cambridge, Cambridge, CB2 0QQ, UK.
³ Faculty of Teacher Education and Sport, Campus Sogndal, Western Norway University of Applied Sciences, Bergen, Norway.
⁴ Department of Sport Medicine, Norwegian School of Sport Sciences, Oslo, Norway.
⁵ Centre for Research in Childhood Health, Exercise Epidemiology Unit, Department of Sport Sciences and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
⁶ Physiotherapy, University College Copenhagen, Copenhagen, Denmark.
⁷ Bristol Medical School, University of Bristol, Bristol, UK.
⁸ Institute of Social and Preventive Medicine, University of Zurich, Zürich, Switzerland.
⁹ Centre for Exercise, Nutrition and health Sciences, School for Policy Studies, University of Bristol, Bristol, UK.
¹⁰ Lausanne University Hospital, Lausanne, Switzerland.
¹¹ School of Psychological Sciences and Health, University of Strathclyde, Glasgow, Scotland.
¹² Exercise and Health Laboratory, CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal.
¹³ UKCRC Centre for Diet and Activity Research (CEDAR), University of Cambridge, Cambridge, UK.

PMID: 31672163
PMCID: PMC6822444
DOI: 10.1186/s12966-019-0858-6

Abstract

Background: Evidence on the association between sitting for extended periods (i.e. prolonged sedentary time (PST)) and cardio-metabolic health is inconsistent in children. We aimed to estimate the differences in cardio-metabolic health associated with substituting PST with non-prolonged sedentary time (non-PST), light (LIPA) or moderate-to-vigorous physical activity (MVPA) in children.

Methods: Cross-sectional data from 14 studies (7 countries) in the International Children's Accelerometry Database (ICAD, 1998-2009) was included. Accelerometry in 19,502 participants aged 3-18 years, together with covariate and outcome data, was pooled and harmonized. Iso-temporal substitution in linear regression models provided beta coefficients (95%CI) for substitution of 1 h/day PST (sedentary time accumulated in bouts > 15 min) with non-PST, LIPA or MVPA, for each study, which were meta-analysed.

Results: Modelling substitution of 1 h/day of PST with non-PST suggested reductions in standardized BMI, but estimates were > 7-fold greater for substitution with MVPA (- 0.44 (- 0.62; - 0.26) SD units). Only reallocation by MVPA was beneficial for waist circumference (- 3.07 (- 4.47; - 1.68) cm), systolic blood pressure (- 1.53 (- 2.42; - 0.65) mmHg) and clustered cardio-metabolic risk (- 0.18 (- 0.3; - 0.1) SD units). For HDL-cholesterol and diastolic blood pressure, substitution with LIPA was beneficial; however, substitution with MVPA showed 5-fold stronger effect estimates (HDL-cholesterol: 0.05 (0.01; 0.10) mmol/l); diastolic blood pressure: - 0.81 (- 1.38; - 0.24) mmHg).

Conclusions: Replacement of PST with MVPA may be the preferred scenario for behaviour change, given beneficial associations with a wide range of cardio-metabolic risk factors (including adiposity, HDL-cholesterol, blood pressure and clustered cardio-metabolic risk). Effect estimates are clinically relevant (e.g. an estimated reduction in waist circumference of ≈1.5 cm for 30 min/day replacement). Replacement with LIPA could be beneficial for some of these risk factors, however with substantially lower effect estimates.

Keywords: ALSPAC; Cardio-metabolic; ICAD; Iso-temporal; Physical activity; Prolonged sitting.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

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Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry database (ICAD)

Collaborators

Affiliations

Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry database (ICAD)

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical