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Review
. 2019 Oct 26:14:29.
doi: 10.1186/s13027-019-0243-8. eCollection 2019.

A meta-analysis of the relationship between vaginal microecology, human papillomavirus infection and cervical intraepithelial neoplasia

Yuejuan Liang  1 , Mengjie Chen  1 , Lu Qin  1 , Bing Wan  1 , He Wang  1
Affiliations
Review

A meta-analysis of the relationship between vaginal microecology, human papillomavirus infection and cervical intraepithelial neoplasia

Yuejuan Liang et al. Infect Agent Cancer. .

Erratum in

Abstract

Microecology is an emerging discipline in recent years. The female reproductive tract is an important microecological region, and its microecological environment can directly affect women's cervical health. This meta-analysis aimed to analyze the effects of vaginal microecology on Human papillomavirus (HPV) infection and cervical intraepithelial neoplasia (CIN). PubMed and Web of Science were systematically searched for eligible publications from January 2000 to December 2017. Articles were selected on the basis of specific inclusion and exclusion criteria. The design and quality of all studies were evaluated using the Newcastle-Ottawa Scale (NOS). Odds ratios (ORs) with a 95% confidence interval (95% CI) were calculated. Thirteen eligible studies were selected to evaluate the association of vaginal microecology with HPV infection and CIN. The factors related to HPV infection were bacterial vaginosis (BV) (OR 2.57, 95% CI 1.78-3.71, P<0.05), Candida albicans (VVC) (OR 0.63, 95% CI 0.49-0.82, P < 0.05), Chlamydia trachomatis (CT) (OR 3.16, 95% CI 2.55-3.90, P < 0.05), and Ureaplasma urealyticum (UU) (OR 1.35, 95% CI 1.20-1.51, P < 0.05). BV was also related to CIN (OR 1.56, 95% CI 1.21-2.00, P < 0.05). This meta-analysis of available literature suggested an intimate association of vaginal microecology and HPV infection with CIN. BV, CT and UU were associated to increased HPV infection, VVC was associated to decreased HPV infection, Lactobacillus is not associated to increased HPV infection, BV was associated to increased CIN development risk. Further large-scale studies are needed to confirm our findings.

Keywords: CIN; HPV; Meta-analysis; Vaginal microecology.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Comparison of BV in the HPV-positive and -negative groups
Fig. 2
Fig. 2
Comparison of VVC in the HPV-positive and -negative groups
Fig. 3
Fig. 3
Comparison of TV in the HPV-positive and -negative groups
Fig. 4
Fig. 4
Comparison of CT in the HPV-positive and -negative groups
Fig. 5
Fig. 5
Comparison of UU in the HPV-positive and -negative groups
Fig. 6
Fig. 6
Comparison of BV in the CIN group and control group
Fig. 7
Fig. 7
Comparison of TV in the CIN group and control group
Fig. 8
Fig. 8
Comparison of VVC in the CIN group and control group
See this image and copyright information in PMC

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