Suboptimal validity of amyloid imaging-based diagnosis and management of Alzheimer's disease: why it is time to abandon the approach

Abass Alavi¹, Jorge R Barrio², Thomas J Werner³, Mohsen Khosravi⁴, Andrew Newberg^{4

5}, Poul Flemming Høilund-Carlsen^{6

7}

Affiliations

¹ Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA. abass.alavi@uphs.upenn.edu.
² David Geffen UCLA School of Medicine, Los Angeles, CA, 90095, USA.
³ Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
⁴ Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA.
⁵ Department of Integrative Medicine and Nutritional Sciences, Marcus Institute of Integrative Health, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
⁶ Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.
⁷ Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

Editorial

Abass Alavi et al. Eur J Nucl Med Mol Imaging. 2020 Feb.

. 2020 Feb;47(2):225-230.

doi: 10.1007/s00259-019-04564-5.

Abass Alavi¹, Jorge R Barrio², Thomas J Werner³, Mohsen Khosravi⁴, Andrew Newberg^{4

5}, Poul Flemming Høilund-Carlsen^{6

7}

¹ Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA. abass.alavi@uphs.upenn.edu.
² David Geffen UCLA School of Medicine, Los Angeles, CA, 90095, USA.
³ Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
⁴ Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA.
⁵ Department of Integrative Medicine and Nutritional Sciences, Marcus Institute of Integrative Health, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
⁶ Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.
⁷ Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

No abstract available

Comment in

Proven validity and management impact of amyloid imaging in Alzheimer's disease-repetita juvant.
Barthel H, Arbizu J, Drzezga A, Garibotto V, Lammertsma AA, Morbelli S; EANM Neuroimaging Committee. Barthel H, et al. Eur J Nucl Med Mol Imaging. 2020 Jul;47(8):1787-1790. doi: 10.1007/s00259-020-04742-w. Eur J Nucl Med Mol Imaging. 2020. PMID: 32130450 No abstract available.