A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Affiliations

¹ Stroke Theme and NHRMC CRE in Stroke Rehabilitation and Brain Recovery, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
² Departement de Neurosciences, Université de Montréal, Montréal, Québec, Canada.
³ Department of Clinical Neuroscience, Central Clinical School, Monash University; Alfred Health, Melbourne, Australia.
⁴ Department of Clinical and Motor Neuroscience, UCL Queen Square Institute of Neurology, London, UK.
⁵ Department of Rehabilitation Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
⁶ Leeds Institute of Clinical Trial Research, University of Leeds, Leeds, UK.
⁷ Melbourne Medical School, University of Melbourne, Melbourne, Australia.
⁸ Department of Physical Therapy & Centre for Brain Health, University of British Columbia, Vancouver, Canada.
⁹ Psychology Department and Institute for Neuroscience, University of Texas at Austin, Austin, TX, USA.
¹⁰ Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
¹¹ Cellular & Molecular Medicine and Canadian Partnership for Stroke Recovery, University of Ottawa, Ottawa, Canada.
¹² Department of Neurology, David Geffen School of Medicine at UCLA; California Rehabilitation Institute, Los Angeles, CA, USA.

PMID: 31674274
DOI: 10.1177/1545968319888642

A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Julie Bernhardt et al. Neurorehabil Neural Repair. 2019 Nov.

. 2019 Nov;33(11):959-969.

doi: 10.1177/1545968319888642. Epub 2019 Nov 1.

Authors

Affiliations

¹ Stroke Theme and NHRMC CRE in Stroke Rehabilitation and Brain Recovery, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
² Departement de Neurosciences, Université de Montréal, Montréal, Québec, Canada.
³ Department of Clinical Neuroscience, Central Clinical School, Monash University; Alfred Health, Melbourne, Australia.
⁴ Department of Clinical and Motor Neuroscience, UCL Queen Square Institute of Neurology, London, UK.
⁵ Department of Rehabilitation Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
⁶ Leeds Institute of Clinical Trial Research, University of Leeds, Leeds, UK.
⁷ Melbourne Medical School, University of Melbourne, Melbourne, Australia.
⁸ Department of Physical Therapy & Centre for Brain Health, University of British Columbia, Vancouver, Canada.
⁹ Psychology Department and Institute for Neuroscience, University of Texas at Austin, Austin, TX, USA.
¹⁰ Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
¹¹ Cellular & Molecular Medicine and Canadian Partnership for Stroke Recovery, University of Ottawa, Ottawa, Canada.
¹² Department of Neurology, David Geffen School of Medicine at UCLA; California Rehabilitation Institute, Los Angeles, CA, USA.

PMID: 31674274
DOI: 10.1177/1545968319888642

Abstract

A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In this paper, we describe key issues for the next generation of stroke recovery treatment trials and present the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar (an upper limb recovery trial) is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development.

Keywords: GO NO-GO; Stroke; consensus; recovery; rehabilitation; trial design.

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A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Affiliations

A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Authors

Affiliations

Abstract

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical