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. 2019 Nov;22(5):250-255.
doi: 10.14744/AnatolJCardiol.2019.90349.

Association between serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris

Buğra Özkan  1 , Özcan Örsçelik  1 , Hatice Yıldırım Yaroğlu  2 , Şenay Balcı  2 , Mert Koray Özcan  1 , Ahmet Çelik  1 , Ismail Türkay Özcan  1
Affiliations

Association between serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris

Buğra Özkan et al. Anatol J Cardiol. 2019 Nov.

Abstract

Objective: Dilation of one or more coronary artery segments to a diameter at least 1.5 times that of a normal adjacent segment is referred to as coronary artery ectasia (CAE). Adropin is a protein involved in endothelial function and is shown to have a protective effect on the regulation of cardiac functions. Atherosclerosis and endothelial dysfunction play an important role in the development of CAE. The aim of this study was to investigate the association between serum adropin levels and isolated CAE.

Methods: Patients with stable angina pectoris who underwent coronary angiography (CAG) between August 2017 and July 2018 were evaluated prospectively. A total of 92 subjects were included in the study-40 patients over 18 years old and diagnosed with isolated CAE based on CAG findings and a control group of 52 patients.

Results: Serum adropin level was found to be significantly lower in the isolated CAE group compared to the control group (1019.57 pg/mL and 1151.10 pg/mL, respectively, p=0.010). The isolated CAE group also exhibited a significantly higher mean platelet volume than that in the control group (10.75 fL and 10.17 fL, respectively, p=0.011).

Conclusion: Our results show that there is an association between low serum adropin level and isolated CAE.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Receiver operating characteristic curve for the determination of the cut-off for adropin level and coronary artery ectasia
See this image and copyright information in PMC

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