Clarifying the HOPE Act landscape: The challenge of donors with false-positive HIV results

Christine M Durand¹, William Werbel¹, Brianna Doby¹, Diane Brown¹, Niraj M Desai², Maricar Malinis³, Jennifer Price⁴, Peter Chin-Hong⁴, Shikha Mehta⁵, Rachel Friedman-Moraco⁶, Nicole A Turgeon⁶, Alexander Gilbert⁷, Michele I Morris⁸, Valentina Stosor⁹, Nahel Elias¹⁰, Saima Aslam¹¹, Carlos A Q Santos¹², Jonathan M Hand¹³, Jennifer Husson¹⁴, Timothy L Pruett¹⁵, Avinash Agarwal¹⁶, Oluwafisayo Adebiyi¹⁷, Marcus Pereira¹⁸, Catherine B Small¹⁹, Senu Apewokin²⁰, Dong Heun Lee²¹, Ghady Haidar²², Emily Blumberg²³, Sapna A Mehta²⁴, Shirish Huprikar²⁵, Sander S Florman²⁶, Andrew D Redd²⁷, Aaron A R Tobian²⁸, Dorry L Segev²

Affiliations

¹ Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
² Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
³ Department of Medicine, Yale School of Medicine, New Haven, Connecticut.
⁴ Department of Medicine, University of California, San Francisco, San Francisco, California.
⁵ Department of Medicine, University of Alabama School of Medicine, Birmingham, Alabama.
⁶ Department of Surgery, Emory University, Atlanta, Georgia.
⁷ Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
⁸ Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida.
⁹ Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
¹⁰ Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
¹¹ Department of Medicine, University of California, San Diego, San Diego, California.
¹² Department of Medicine, Rush University Medical Center, Chicago, Illinois.
¹³ Department of Medicine, University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, Louisiana.
¹⁴ Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland.
¹⁵ Department of Surgery, University of Minnesota Medical Center, Minneapolis, Minnesota.
¹⁶ Department of Surgery, University of Virginia Medical Center, Charlottesville, Virginia.
¹⁷ Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
¹⁸ Department of Medicine, Columbia University Irving Medical Center, New York, New York.
¹⁹ Department of Medicine, Weill Medical College of Cornell University, New York, New York.
²⁰ Division of Infectious Diseases, Department of Medicine, University of Cincinnati, Cincinnati, Ohio.
²¹ Department of Medicine, Drexel University, Philadelphia, Pennsylvania.
²² Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
²³ Division of Infectious Diseases, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
²⁴ Department of Medicine, New York University School of Medicine, New York, New York.
²⁵ Department of Medicine, Icahn School of Medicine, New York, New York.
²⁶ Recanati-Miller Transplantation Institute, The Mount Sinai Hospital, New York, New York.
²⁷ Division of Intramural Research, NIAID, NIH, Bethesda, Maryland.
²⁸ Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

PMID: 31675457
PMCID: PMC7132607
DOI: 10.1111/ajt.15681

Comment

Clarifying the HOPE Act landscape: The challenge of donors with false-positive HIV results

Christine M Durand et al. Am J Transplant. 2020 Feb.

. 2020 Feb;20(2):617-619.

doi: 10.1111/ajt.15681. Epub 2019 Nov 20.

Authors

Affiliations

¹ Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
² Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
³ Department of Medicine, Yale School of Medicine, New Haven, Connecticut.
⁴ Department of Medicine, University of California, San Francisco, San Francisco, California.
⁵ Department of Medicine, University of Alabama School of Medicine, Birmingham, Alabama.
⁶ Department of Surgery, Emory University, Atlanta, Georgia.
⁷ Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
⁸ Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida.
⁹ Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
¹⁰ Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
¹¹ Department of Medicine, University of California, San Diego, San Diego, California.
¹² Department of Medicine, Rush University Medical Center, Chicago, Illinois.
¹³ Department of Medicine, University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, Louisiana.
¹⁴ Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland.
¹⁵ Department of Surgery, University of Minnesota Medical Center, Minneapolis, Minnesota.
¹⁶ Department of Surgery, University of Virginia Medical Center, Charlottesville, Virginia.
¹⁷ Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
¹⁸ Department of Medicine, Columbia University Irving Medical Center, New York, New York.
¹⁹ Department of Medicine, Weill Medical College of Cornell University, New York, New York.
²⁰ Division of Infectious Diseases, Department of Medicine, University of Cincinnati, Cincinnati, Ohio.
²¹ Department of Medicine, Drexel University, Philadelphia, Pennsylvania.
²² Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
²³ Division of Infectious Diseases, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
²⁴ Department of Medicine, New York University School of Medicine, New York, New York.
²⁵ Department of Medicine, Icahn School of Medicine, New York, New York.
²⁶ Recanati-Miller Transplantation Institute, The Mount Sinai Hospital, New York, New York.
²⁷ Division of Intramural Research, NIAID, NIH, Bethesda, Maryland.
²⁸ Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

PMID: 31675457
PMCID: PMC7132607
DOI: 10.1111/ajt.15681

No abstract available

Keywords: United Network for Organ Sharing (UNOS); clinical research/practice; donors and donation: deceased; ethics and public policy; infection and infectious agents - viral: human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS); infectious disease; kidney disease: infectious; kidney transplantation/nephrology; liver disease: infectious; liver transplantation/hepatology.

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Conflict of interest statement

Disclosure

The authors of this manuscript have conflicts of interest to disclose as described by the American Journal of Transplantation. Dorry L. Segev receives honoraria from Novartis to Speak about HOPE. The other authors have no conflicts of interest to disclose.

Comment on

National landscape of HIV+ to HIV+ kidney and liver transplantation in the United States.
Wilk AR, Hunter RA, McBride MA, Klassen DK. Wilk AR, et al. Am J Transplant. 2019 Sep;19(9):2594-2605. doi: 10.1111/ajt.15494. Epub 2019 Jul 10. Am J Transplant. 2019. PMID: 31207040

References

1. Wilk AR, Hunter RA, McBride MA, Klassen DK. National landscape of HIV+ to HIV+ kidney and liver transplantation in the United States. Am J Transplant. 2019;19(9):2594–605. - PubMed
1. Durand CM, Halpern SE, Bowring MG, Bismut GA, Kusemiju OT, Doby B, et al. Organs from deceased donors with false-positive HIV screening tests: An unexpected benefit of the HOPE act. Am J Transplant. 2018;18(10):2579–86. - PMC - PubMed
1. Wilk AR, Durand CM, Segev DL, Klassen D. Two Years of the HOPE Act. Am J Transplant. 2017;17.
1. Network OPaT;Pages https://optn.transplant.hrsa.gov/media/1200/optn_policies.pdf#nameddest=...on 8/2/2019.
1. Locke JE, Mehta S, Reed RD, MacLennan P, Massie A, Nellore A, et al. A National Study of Outcomes among HIV-Infected Kidney Transplant Recipients. J Am Soc Nephrol. 2015;26(9):2222–9. - PMC - PubMed

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Clarifying the HOPE Act landscape: The challenge of donors with false-positive HIV results

Affiliations

Clarifying the HOPE Act landscape: The challenge of donors with false-positive HIV results

Authors

Affiliations

Conflict of interest statement

Comment on

References

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