The Immune-Mind Connection

Saiyu Hang¹, Jun R Huh²

Affiliations

¹ Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
² Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunological Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: jun_huh@hms.harvard.edu.

PMID: 31675492
DOI: 10.1016/j.cell.2019.10.012

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The Immune-Mind Connection

Saiyu Hang et al. Cell. 2019.

Free article

. 2019 Oct 31;179(4):803-805.

doi: 10.1016/j.cell.2019.10.012.

Authors

Saiyu Hang¹, Jun R Huh²

Affiliations

¹ Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
² Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunological Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: jun_huh@hms.harvard.edu.

PMID: 31675492
DOI: 10.1016/j.cell.2019.10.012

Abstract

How does stress promote anxiety? In this issue of Cell, Fan et al. report that immune cells have a direct role in this process. They show that chronic stress promotes mitochondrial fission in CD4⁺ T cells, causing increased synthesis of xanthine, which acts on the brain and induces anxiety-like behaviors.

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Stress-Induced Metabolic Disorder in Peripheral CD4⁺ T Cells Leads to Anxiety-like Behavior.
Fan KQ, Li YY, Wang HL, Mao XT, Guo JX, Wang F, Huang LJ, Li YN, Ma XY, Gao ZJ, Chen W, Qian DD, Xue WJ, Cao Q, Zhang L, Shen L, Zhang L, Tong C, Zhong JY, Lu W, Lu L, Ren KM, Zhong G, Wang Y, Tang M, Feng XH, Chai RJ, Jin J. Fan KQ, et al. Cell. 2019 Oct 31;179(4):864-879.e19. doi: 10.1016/j.cell.2019.10.001. Cell. 2019. PMID: 31675497

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The Immune-Mind Connection

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The Immune-Mind Connection

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